20.500.12556/RUL-134381 Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their metabolites Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics have a high impact on HCAs to reach the target tissue in order to exert their biological activities. In particular, metabolism is of high importance since HCAs' metabolites could either lose the activity or be even more potent compared to the parent compounds. In this review, natural sources and pharmacokinetic properties of HCAs and their esters are presented and discussed. The main focus is on their metabolism along with biological activities and health benefits. Special emphasis is given on specific effects of HCAs' metabolites in comparison with their parent compounds. diet natural compounds phenolic acids hydroxycinnamic acids metabolites pharmacokinetic properties biological activities health effects true false true Angleški jezik Ni določen Članek v reviji 2022-01-12 11:16:55 2022-01-12 11:16:58 2022-09-13 03:54:50 0000-00-00 00:00:00 2020 0 0 30 str. iss. 8, art. 2190 Vol. 12 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.121:613 2072-6643 10.3390/nu12082190 24845827 RAZ_Sova_Matej_2020.pdf RAZ_Sova_Matej_2020.pdf 1 054B750C82546F5980BD5E9363A46243 a82846f8d89bcfc72023042470bdc8f5c54d20c651760253c15e15f7e2620450 e7098cdb-7390-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152801 https://www.mdpi.com/2072-6643/12/8/2190 0 988ced85-7390-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152799 Fakulteta za farmacijo 0 0 0