Effect of statin use on the clinical manifestations, laboratory test results and outcome of Lyme neuroborreliosis

Ogrinc, Katarina (author), Kastrin, Andrej (author), Lotrič-Furlan, Stanka (author), Bogovič, Petra (author), Rojko, Tereza (author), Cerar Kišek, Tjaša (author), Ružić-Sabljić, Eva (author), Wormser, Gary P. (author), Strle, Franc (author)

Statins have anti-inflammatory and potentially antimicrobial activity, but whether they have a beneficial effect on the course of infectious diseases is controversial. In this study, we assessed the impact of pre-existing statin use on the course and outcome of Lyme neuroborreliosis manifested as meningoradiculitis (Bannwarth’s syndrome). One hundred and twenty three consecutive patients with Bannwarth’s syndrome, of whom 18 (14.6%) were being treated with statins, were included in the study. To assess the influence of statin use on the course and outcome of the disease, univariate and multivariable analyses were performed. No statistically significant association was found between statin pre-treatment and the clinical manifestations, laboratory test results, and outcome of Bannwarth’s syndrome. In conclusion, pre-existing use of statins did not significantly impact either the clinical presentation or the outcome of Bannwarth’s syndrome.

• Language: English
• Keywords: Lyme neuroborreliosis, Bannwarth's syndrome, statin, course, outcome
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 11 str.
• Numbering: Vol. 9, iss. 9, art. 2995
• PID: 20.500.12556/RUL-134358
• UDC: 616.9
• ISSN on article: 2077-0383
• DOI: 10.3390/jcm9092995
• COBISS.SI-ID: 29554435
• Publication date in RUL: 10.01.2022

Record is a part of a journal

• Title: Journal of clinical medicine
• Shortened title: J. clin. med.
• Publisher: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 16.09.2020

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0296
• Name: Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci