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The correlation between extracellular heat shock protein 70 and lipid metabolism in a ruminant model
ID
Petrović, Miloš Ž.
(
Avtor
),
ID
Cincović, M. R.
(
Avtor
),
ID
Starič, Jože
(
Avtor
),
ID
Djoković, Radojica
(
Avtor
),
ID
Belić, B.
(
Avtor
),
ID
Radinović, Miodrag
(
Avtor
),
ID
Majkić, Mira
(
Avtor
),
ID
Ilić, Zoran Ž.
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(679,01 KB)
MD5: 0B648C9034D96EEF7D9A651CFE4FEB08
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2218-1989/12/1/19
Galerija slik
Izvleček
Metabolic stress in early lactation cows is characterized by lipolysis, ketogenesis, insulin resistance and inflammation because of negative energy balance and increased use of lipids for energy needs. In this study the relationship between lipid metabolite, lipid-based insulin resistance, and hepatocyte functionality indexes and tumor necrosis factor alpha (TNF-α) with extracellular heat shock protein 70 (eHsp70) was investigated. The experiment included 50 cows and all parameters were measured in blood serum. In cows with a more pronounced negative energy balance, the following was determined: a higher concentration of eHsp70, TNF-α, non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), NEFA to insulin and NEFA to cholesterol ratio and lower concentration of cholesterol, very low-density lipoproteins (VLDL), low density lipoproteins (LDL) and liver functionality index (LFI). The eHsp70 correlated negatively with the values of cholesterol, VLDL, LDL, and triglycerides, while correlated positively with the level of NEFA and BHB. A higher concentration of eHsp70 suggests the development of fatty liver (due to a higher NEFA to cholesterol ratio and lower LFI) and insulin resistance (due to a lower revised quantitative insulin sensitivity check index RQUICKI-BHB and higher NEFA to insulin ratio). The eHsp70 correlated positively with TNF-α. Both TNF-α and eHsp70 correlated similarly to lipid metabolites. In cows with high eHsp70 and TNF-α values we found higher concentrations of NEFA, BHB, NEFA to insulin and NEFA to cholesterol ratio and a lower concentration of triglycerides and VLDL cholesterol compared to cows that had only high TNF-α values. Based on the positive correlation between eHsp70 and TNF-α, their similar relations, and the additional effect of eHsp70 (high TNF-α + eHsp70 values) on lipid metabolites we conclude that eHsp70 has pro-inflammatory effects implicating lipolysis, fatty liver, and fat tissue insulin resistance.
Jezik:
Angleški jezik
Ključne besede:
cow
,
early lactation
,
chaperons
,
lipolysis
,
ketogensis
,
insulin resistance
,
fatty liver
,
negative energy balance
,
cattle
,
lactation
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
14 str.
Številčenje:
Vol. 12, iss. 1, art. 19
PID:
20.500.12556/RUL-134220
UDK:
636.09:542
ISSN pri članku:
2079-6382
DOI:
10.3390/metabo12010019
COBISS.SI-ID:
91366915
Datum objave v RUL:
30.12.2021
Število ogledov:
1443
Število prenosov:
146
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Metabolites
Skrajšan naslov:
Metabolites
Založnik:
MDPI
ISSN:
2218-1989
COBISS.SI-ID:
523274009
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.01.2022
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Ministry of Education, Science and Technological Development
Številka projekta:
451-03-9/2021-14/200117
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