Synthetic biology approaches to actinomycete strain improvement

Breitling, Rainer (author), Avbelj, Martina (author), Bilyk, Oksana (author), Del Carratore, Francesco (author), Filisetti, Alessandro (author), Hanko, Erik K. R. (author), Iorio, Marianna (author), Pérez Redondo, Rosario (author), Reyes, Fernando (author), Rudden, Michelle (author), Severi, Emmanuele (author), Slemc, Lucija (author), Schmidt, Kamila (author), Whittall, Dominic R. (author), Donadio, Stefano (author), Rodríguez García, Antonio (author), Genilloud, Olga (author), Kosec, Gregor (author), De Lucrezia, Davide (author), Petković, Hrvoje (author), Thomas, Gavin (author), Takano, Eriko (author)

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

• Language: English
• Keywords: actinomycete, synthetic biology, actinobacteria, biosynthesis, biotechnology
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 19 str.
• Numbering: Vol. 368, iss. 10, art. fnab060
• PID: 20.500.12556/RUL-134064
• UDC: 602.3:579.873
• ISSN on article: 0378-1097
• DOI: 10.1093/femsle/fnab060
• COBISS.SI-ID: 65719811
• Publication date in RUL: 23.12.2021

Record is a part of a journal

• Title: FEMS microbiology letters
• Shortened title: FEMS microbiol. lett.
• Publisher: Oxford
• ISSN: 0378-1097
• COBISS.SI-ID: 25455104

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 31.05.2021

Secondary language

• Language: Slovenian
• Keywords: aktinomicete, biosinteza

Projects

• Funder: EC - European Commission
• Funding programme: H2020
• Project number: 720793
• Name: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients
• Acronym: TOPCAPI