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HIV-1 unique recombinant forms identified in Slovenia and their characterization by near full-length genome sequencing
ID
Lunar, Maja M.
(
Avtor
),
ID
Mlakar, Jana
(
Avtor
),
ID
Zorec, Tomaž Mark
(
Avtor
),
ID
Poljak, Mario
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(2,65 MB)
MD5: 357A094179D14A8C24121BF33AADD4C5
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1999-4915/12/1/63
Galerija slik
Izvleček
Surveillance of HIV circulating recombinant forms (CRFs) is important because HIV diversity can affect various aspects of HIV infection from prevention to diagnosis and patient management. A comprehensive collection of pol sequences obtained from individuals diagnosed with HIV-1 from 2000 to 2016 in Slovenia was subtyped to identify possible unique recombinant forms (URFs). Selected samples were subjected to near full-length genome (NFLG) sequencing and detailed recombination analyses. Discordant subtyping results were observed for 68/387 (17.6%) sequences and 20 sequences were identified as the most probable URFs and selected for NFLG characterization. Further, 11 NFLGs and two sequences of >7000 base pairs were obtained. Seven sequences were identified as "pure" subtypes or already characterized CRFs: subtype B (n = 5), sub-subtype A6 (n = 1), and CRF01_AE (n = 1). The remaining six sequences were determined to be URFs; four displayed a single recombination event and two exhibited a complex recombination pattern involving several subtypes or CRFs. Finally, three HIV strains were recognized as having epidemic potential and could be further characterized as new CRFs. Our study shows that the identification of new CRFs is possible, even in countries where HIV diversity is considered limited, emphasizing the importance of the surveillance of HIV recombinant forms.
Jezik:
Angleški jezik
Ključne besede:
molecular epidemiology
,
HIV-1
,
subtype
,
unique recombinant form
,
near full-length genome
,
next-generation sequencing
,
surveillance
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
22 str.
Številčenje:
Vol. 12, iss. 1, art. 63
PID:
20.500.12556/RUL-133285
UDK:
616.9
ISSN pri članku:
1999-4915
DOI:
10.3390/v12010063
COBISS.SI-ID:
34697433
Datum objave v RUL:
19.11.2021
Število ogledov:
1354
Število prenosov:
137
Metapodatki:
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Gradivo je del revije
Naslov:
Viruses
Skrajšan naslov:
Viruses
Založnik:
MDPI
ISSN:
1999-4915
COBISS.SI-ID:
517597977
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
03.01.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
molekularna epidemiologija
,
HIV-1
,
podtip
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