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Sexual dimorphism of the extraorbital lacrimal glands in SF-1 knockout mice
ID Šemanjski, Kristina (Avtor), ID Majdič, Gregor (Avtor), ID Kozina, Viviana (Avtor), ID Ježek, Davor (Avtor)

URLURL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0065128120301689?via%3Dihub Povezava se odpre v novem oknu

Izvleček
ABSTRACT Sexual dimorphism (SD) represents all the differences between males and females of the same species. SD of the murine lacrimal gland and the major effect of testosterone on its formation are well documented. Steroidogenic factor-1 (SF-1, NR5a1) is a nuclear receptor essential for the fetal development of steroid hormones producing organs and SF-1 knockout mice (Sf-1 KO) are therefore born without gonads and adrenal glands. The aim of this study was to investigate whether SD in lacrimal glands is present in the absence of exposure to sex hormones during development. Lacrimal glands from adult Sf-1 KO male and female mice without hormonal exposure, and from males that were treated with testosterone propionate (TP) prior to sacrifice, were examined. After sacrifice, glandular tissue was processed using standard histological procedures. Paraffin sections were analysed by ste-reology and immunostained against the androgen receptor (AR). Our results showed that there were no statis-tically significant differences in the mean volumes of acini, connective tissue or ductal system between males, females, and males on TP. The same pertains to the mean length of the ducts in all three groups. In the absence of sex hormones, sex chromosomes proved to be insufficient in inducing sexual dimorphism in LG. However, nuclei of the acinar cells in males on TP were positive for AR, whereas in males without TP no expression of AR was detected. Administration of TP induced the expression of AR in the nuclei of acinar cells of males but did not affect the morphology of LG. We conclude that SD in the lacrimal gland is not present in Sf-1 KO mice and this suggests that sex hormones have a major role in the development of SD in the lacrimal gland.

Jezik:Angleški jezik
Ključne besede:Sexual dimorphism, lacrimal gland, testosterone, Sf-1 KO mice
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Recenzirani rokopis
Datum objave:25.12.2020
Leto izida:2021
Št. strani:7 str.
Številčenje:Vol. 123, no. 2, art. 151669
PID:20.500.12556/RUL-132237 Povezava se odpre v novem oknu
UDK:636.09:575
ISSN pri članku:1618-0372
DOI:10.1016/j.acthis.2020.151669 Povezava se odpre v novem oknu
COBISS.SI-ID:46732035 Povezava se odpre v novem oknu
Datum objave v RUL:18.10.2021
Število ogledov:660
Število prenosov:33
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Gradivo je del revije

Naslov:Acta histochemica
Skrajšan naslov:Acta histochem.
Založnik:Elsevier
ISSN:1618-0372
COBISS.SI-ID:46718211 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:25.12.2020

Projekti

Financer:MZOS - Ministry of Science, Education and Sports of the Republic of Croatia
Številka projekta:108-1080399-0383
Naslov:Male and female reproductive tract: development, histophysiology and infertility

Financer:EC - European Commission
Program financ.:European Union through the European Regional Development Fund
Številka projekta:KK.01.1.1.01.0008
Naslov:Regenerative and Reproductive Medicine - Exploring New Platforms and Potentials

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