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Evaluation of oxidative stress parameters in dogs with brachycephalic obstructive airway syndrome before and after surgery
Erjavec, Vladimira (Author), Vovk, Tomaž (Author), Nemec Svete, Alenka (Author)

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Abstract
Abstract Introduction: Canine brachycephalic obstructive airway syndrome (BOAS) is a conformation-related respiratory disorder of dog breeds having congenitally flattened facial and skull anatomy. The aim of the study was to determine oxidative stress parameters, the lipid peroxidation product malondialdehyde, and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase in BOAS patients before and after surgical treatment and in healthy brachycephalic dogs. Material and Methods: Nine healthy brachycephalic dogs that had not undergone surgery and 39 BOAS patients were included in the study. The BOAS patients were classified as grade 1 (5/34), grade 2 (16/34), and grade 3 (13/34) based on the decrease in the radius of the airway in the larynx. In BOAS patients, oxidative stress parameters were determined before and two weeks after surgery, while in control dogs, blood samples were collected only on inclusion to the study. Results: All BOAS patients showed various degrees of improvement in clinical signs after surgery. Significantly lower (P < 0.05) SOD activity was found in grade 2 and 3 BOAS patients than in grade 1 patients. Two weeks after surgery, a significant (P < 0.05) increase in SOD activity in grade 2 and 3 patients was observed. Conclusion: Antioxidant enzyme SOD may play an important role in BOAS and can be used as a biomarker of antioxidant status assessment in BOAS patients.

Language:English
Keywords:brachycephalic obstructive airway syndrome, malondialdehyde, superoxide dismutase, glutathione peroxidase, oral surgery
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:VF - Veterinary Faculty
FFA - Faculty of Pharmacy
Year:2021
Submitted for review:30.09.2020
Article acceptance date:07.05.2021
Article publication date:22.05.2021
Number of pages:Str. 201-208
Numbering:Vol. 65, no. 2
UDC:636.7.09:616
ISSN on article:2450-7393
DOI:10.2478/jvetres-2021-0027 This link opens in a new window
COBISS.SI-ID:64497411 This link opens in a new window
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Downloads:27
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Record is a part of a journal

Title:Journal of Veterinary Research
Shortened title:J. Vet. Res.
Publisher:National Veterinary Research Institute
ISSN:2450-7393
COBISS.SI-ID:4727418 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P4-0053
Name:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

Licences

License:CC BY-NC 3.0, Creative Commons Attribution-NonCommercial 3.0 Unported
Link:http://creativecommons.org/licenses/by-nc/3.0/
Description:You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Licensing start date:22.05.2021

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