20.500.12556/RUL-132095 Evaluation of oxidative stress parameters in dogs with brachycephalic obstructive airway syndrome before and after surgery Abstract Introduction: Canine brachycephalic obstructive airway syndrome (BOAS) is a conformation-related respiratory disorder of dog breeds having congenitally flattened facial and skull anatomy. The aim of the study was to determine oxidative stress parameters, the lipid peroxidation product malondialdehyde, and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase in BOAS patients before and after surgical treatment and in healthy brachycephalic dogs. Material and Methods: Nine healthy brachycephalic dogs that had not undergone surgery and 39 BOAS patients were included in the study. The BOAS patients were classified as grade 1 (5/34), grade 2 (16/34), and grade 3 (13/34) based on the decrease in the radius of the airway in the larynx. In BOAS patients, oxidative stress parameters were determined before and two weeks after surgery, while in control dogs, blood samples were collected only on inclusion to the study. Results: All BOAS patients showed various degrees of improvement in clinical signs after surgery. Significantly lower (P < 0.05) SOD activity was found in grade 2 and 3 BOAS patients than in grade 1 patients. Two weeks after surgery, a significant (P < 0.05) increase in SOD activity in grade 2 and 3 patients was observed. Conclusion: Antioxidant enzyme SOD may play an important role in BOAS and can be used as a biomarker of antioxidant status assessment in BOAS patients. brachycephalic obstructive airway syndrome malondialdehyde superoxide dismutase glutathione peroxidase oral surgery true false true Angleški jezik Ni določen Članek v reviji 2021-10-12 13:08:58 2021-10-12 13:08:59 2022-09-12 04:11:01 0000-00-00 00:00:00 2021 0 0 Str. 201-208 no. 2 Vol. 65 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2020-09-30 2021-05-07 2021-05-22 636.7.09:616 2450-7393 10.2478/jvetres-2021-0027 64497411 RAZ_Erjavec_Vladimira_2021.pdf RAZ_Erjavec_Vladimira_2021.pdf 1 FA181851ADE50596B691FBC106DFA925 f089a9fbe412d668868c36e5fc38426d4d6bbfcfb4d1ab901e01ce063f69870b d7fd3d38-2ce9-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149706 https://www.sciendo.com/article/10.2478/jvetres-2021-0027 1 cdac7f34-2b4c-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149617 Veterinarska fakulteta Fakulteta za farmacijo 0 0 0