Sinteza metil 6-(morfolin-4-karbonil)pikolinata in možnosti njegove uporabe kot liganda v kompleksih z antidiabetičnim delovanjem

Hudej, Branka (author), Perdih, Franc (mentor)

Sladkorna bolezen ali diabetes je presnovna bolezen, ki postaja vedno bolj razširjena. Želja je razviti učinkovito zdravilo za lajšanje življenja diabetikov. Obetavni so kompleksi cinkovih in vanadijevih ionov z organskimi ligandi, saj bi lahko nadomestili zdravljenje z inzulinom in sintetičnimi peroralnimi antidiabetiki, ki imajo številne stranske učinke. Diplomsko delo obsega dvostopenjsko sintezo metil 6-(morfolin-4-karbonil)pikolinata, ki je po hidrolizi primeren za sintezo kompleksov s potencialnimi antidiabetičnimi lastnostmi. Izhodno spojino, metil 6-(metoksikarbonil)pikolinsko kislino, sem najprej pretvorila v kislinski klorid. Po substituciji klorovega atom z morfolinom sem dobila produkt in ga karakterizirala z NMR analizo.

• Language: Slovenian
• Keywords: vanadij, cink, sladkorna bolezen, koordinacijske spojine, antidiabetične lastnosti
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2021
• PID: 20.500.12556/RUL-130811
• COBISS.SI-ID: 85261315
• Publication date in RUL: 17.09.2021

Secondary language

• Language: English
• Title: Synthesis of methyl 6-(morpholine-4-carbonyl)picolinate and possibilities of its use as a ligand in complexes with antidiabetic activity

Abstract

Diabetes is a metabolic disease that is becoming more prevalent. We wish to develope an effective drug to make life easier for diabetics. Complexes of zinc and vanadium ions with organic ligands showed a lot of promise in replacing treatment with insulin and synthetic oral antidiabetics, that have many side effects. Thesis includes two-stage synthesis of methyl 6-(morpholine-4-carbonyl)picolinate, which is, after hydrolysis, suitable for synthesis of complexes with potential antidiabetic properties. I first converted the starting product, methyl 6-(methoxycarbonyl)picolinic acid, to acid chloride. After substitution of the chlorine atom with morpholine, I obtained a product and characterized it with NMR analysis.

• Keywords: vanadium, zinc, diabetes, coordination compounds, antidiabetic properties