Method for controlled tissue theranostics using a single tunable laser source
Podlipec, Rok (Author), Mur, Jaka (Author), Petelin, Jaka (Author), Štrancar, Janez (Author), Petkovšek, Rok (Author)

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Tissue diseases and related disorders need to be first recognized using diagnostic methods and then later treated by therapeutic methods–a joint procedure called theranostics. One of the main challenges in the field of retinal therapies remains in the success of the treatment, typically improving the local metabolism, by sparing the surrounding tissue and with the immediate information of the laser effect. In our study, we present a concept for real-time controlled tissue theranostics on a proof-of-concept study capable of using a single tunable ps laser source (in terms of irradiance, fluence, and repetition rate), done on ex-vivo human retinal pigment epithelium. We have found autofluorescence intensity and lifetime imaging diagnostics very promising for the recognition and quantification of laser effects ranging from selective non-destructive molecular tissue modification to complete tissue ablation. The main novelty of our work presents the developed algorithm for optimized theranostics based on the model function used to quantify laser-induced tissue changes through the diagnostics descriptors, fluorescence lifetime and fluorescence intensity parameters. This approach, together with the operation of the single adaptable laser source, can serve as a new theranostics method in personalized medicine in the future not only limited to treat retinal diseases.

Keywords:adaptable fiber lasers, retinal tissue, theranostics, multimodal imaging, fluorescence lifetime imaging
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Number of pages:Str. 5881-1-5881-13
Numbering:Vol. 12, no. 9
ISSN on article:2156-7085
DOI:10.1364/BOE.428467 This link opens in a new window
COBISS.SI-ID:75069699 This link opens in a new window
Copyright:V članku navedeno: "© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement"; s povezavo https://www.osapublishing.org/library/license_v1.cfm. (6. 9. 2021)
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Record is a part of a journal

Title:Biomedical optics express
Shortened title:Biomed. opt. express
Publisher:Optical Society of America
COBISS.SI-ID:24857383 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L2-9240
Name:Ultrakratki laserski pulzi na zahtevo

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L2-9254
Name:Prostorsko in časovno oblikovanje laserske svetlobe za minimalno invazivne oftalmološke posege

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L7-7561
Name:Mikrospektroskopska karakterizacija in optimizacija učinka laserskih sunkov na očesni mrežnici

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P2-0270
Name:Proizvodni sistemi, laserske tehnologije in spajanje materialov

Secondary language

Keywords:prilagodljivi vlakenski laserji, tkivo mrežnice, teranostika, multimodalno slikanje, življenjski čas fluorescence

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