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Astrocytic vesicle mobility in health and disease
ID Potokar, Maja (Author), ID Vardjan, Nina (Author), ID Stenovec, Matjaž (Author), ID Trkov Bobnar, Saša (Author), ID Jorgačevski, Jernej (Author), ID Kreft, Marko (Author), ID Zorec, Robert (Author)

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Abstract
Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.

Language:English
Keywords:astrocyte, glia, vesicle, trafficking, gliotransmitter, antigen presentation, neuroinflammation, amyotrophic lateral sclerosis, multiple sclerosis
Work type:Article (dk_c)
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
BF - Biotechnical Faculty
Year:2013
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:Str. 11238-11258
Numbering:Vol. 14, iss. 6
UDC:616-092
ISSN on article:1661-6596
DOI:10.3390/ijms140611238 This link opens in a new window
COBISS.SI-ID:30620377 This link opens in a new window
Publication date in RUL:31.08.2021
Views:291
Downloads:61
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1661-6596
COBISS.SI-ID:36217605 This link opens in a new window

Licences

License:CC BY 3.0, Creative Commons Attribution 3.0 Unported
Link:https://creativecommons.org/licenses/by/3.0/deed.en
Description:You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Licensing start date:01.06.2013

Secondary language

Language:Slovenian
Keywords:glija, astrociti, multipla skleroza

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:P3-0310
Name:Celična fiziologija1 10-7

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-4051
Name:Vloga monomernih GTPaz pri uravnavanju mobilnosti endosomov/lizosomov v astrocitih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-4146
Name:Mobilnost sekrecijskih mešičkov in homeostaza kalcija v astrocitih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:L3-3654
Name:Simulacija breztežnosti in zmanjšane težnosti: učinki na kardiovaskularni in na mišičnoskeletni sistem

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3 3236

Funder:Drugi - Drug financer ali več financerjev
Funding programme:CIPKEBIP

Funder:Drugi - Drug financer ali več financerjev
Funding programme:COST
Acronym:Nanonet

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