Astrocytic vesicle mobility in health and disease

Potokar, Maja (author), Vardjan, Nina (author), Stenovec, Matjaž (author), Trkov, Saša (author), Jorgačevski, Jernej (author), Kreft, Marko (author), Zorec, Robert (author)

Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.

• Language: English
• Keywords: astrocyte, glia, vesicle, trafficking, gliotransmitter, antigen presentation, neuroinflammation, amyotrophic lateral sclerosis, multiple sclerosis
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine; BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2013
• Number of pages: Str. 11238-11258
• Numbering: Vol. 14, iss. 6
• PID: 20.500.12556/RUL-129252
• UDC: 616-092
• ISSN on article: 1661-6596
• DOI: 10.3390/ijms140611238
• COBISS.SI-ID: 30620377
• Publication date in RUL: 31.08.2021

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1661-6596
• COBISS.SI-ID: 36217605

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
• Licensing start date: 01.06.2013

Secondary language

• Language: Slovenian
• Keywords: glija, astrociti, multipla skleroza