20.500.12556/RUL-129252 Astrocytic vesicle mobility in health and disease Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions. astrocyte glia vesicle trafficking gliotransmitter antigen presentation neuroinflammation amyotrophic lateral sclerosis multiple sclerosis glija astrociti multipla skleroza true false true Angleški jezik Slovenski jezik Članek v reviji 2021-08-31 12:50:19 2021-08-31 12:50:24 2023-05-05 13:05:07 0000-00-00 00:00:00 2013 0 0 Str. 11238-11258 iss. 6 Vol. 14 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 1661-6596 10.3390/ijms140611238 30620377 RAZ_Potokar_Maja_2013.pdf RAZ_Potokar_Maja_2013.pdf 1 5D230D956D26F25AF705FAF244B0814C f1fbb94e74ae2bace879f02103494ac4f4741deadfa443401b631edf3660144c 6c50eee8-0a49-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146219 https://www.mdpi.com/1422-0067/14/6/11238 0 4b9436dd-0a49-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146218 Medicinska fakulteta Biotehniška fakulteta 0 0 0