Aldo-keto reductase 1C3 - assessment as a new target for the treatment of endometriosis

Lanišnik-Rižner, Tea (author), Penning, Trevor M. (author)

Endometriosis is a common gynecological disorder, which is treated surgically and/ or pharmacologically with an unmet clinical need for new therapeutics. A completed phase I trial and a recent phase II trial that investigated the steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor BAY1128688 in endometriosis patients prompted this critical assessment on the role of AKR1C3 in endometriosis. This review includes an introduction to endometriosis with emphasis on the roles of prostaglandins and progesterone in its pathophysiology. This is followed by an overview of the major enzymatic activities and physiological functions of AKR1C3 and of the data published to date on the expression of AKR1C3 in endometriosis at the mRNA and protein levels. The review concludes with the rationale for using AKR1C3 inhibitors, a discussion of the effects of AKR1C3 inhibition on the pathophysiology of endometriosis and a brief overview of other drugs under clinical investigation for this indication.

• Language: English
• Keywords: progesterone, androgens, endometriosis, prostaglandin F$_2$$_α$, 9α, 11β-prostaglandin F$_2$, geranylgeranial, 9-cis-retinoic acid
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 14 str.
• Numbering: Vol. 152, art. 104446
• PID: 20.500.12556/RUL-128777
• UDC: 618.1
• ISSN on article: 1096-1186
• DOI: 10.1016/j.phrs.2019.104446
• COBISS.SI-ID: 34486233
• Publication date in RUL: 28.07.2021

Record is a part of a journal

• Title: Pharmacological research
• Shortened title: Pharmacol. res.
• Publisher: Elsevier
• ISSN: 1096-1186
• COBISS.SI-ID: 53047811

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: progesteron, androgeni, endometrioza

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: J3-8212
• Name: Vloga intrakrinega delovanja estrogenov pri hormonsko odvisnih boleznih – pomen za zdravljenje

• Funder: Other - Other funder or multiple funders
• Project number: P30-ES013508