20.500.12556/RUL-128777 Aldo-keto reductase 1C3 - assessment as a new target for the treatment of endometriosis Endometriosis is a common gynecological disorder, which is treated surgically and/ or pharmacologically with an unmet clinical need for new therapeutics. A completed phase I trial and a recent phase II trial that investigated the steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor BAY1128688 in endometriosis patients prompted this critical assessment on the role of AKR1C3 in endometriosis. This review includes an introduction to endometriosis with emphasis on the roles of prostaglandins and progesterone in its pathophysiology. This is followed by an overview of the major enzymatic activities and physiological functions of AKR1C3 and of the data published to date on the expression of AKR1C3 in endometriosis at the mRNA and protein levels. The review concludes with the rationale for using AKR1C3 inhibitors, a discussion of the effects of AKR1C3 inhibition on the pathophysiology of endometriosis and a brief overview of other drugs under clinical investigation for this indication. progesterone androgens endometriosis prostaglandin F$_2$$_α$ 9α 11β-prostaglandin F$_2$ geranylgeranial 9-cis-retinoic acid progesteron androgeni endometrioza true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-28 14:45:54 2021-07-28 14:45:56 2022-09-07 04:17:08 0000-00-00 00:00:00 2020 0 0 14 str. Vol. 152, art. 104446 Feb. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 1096-1186 10.1016/j.phrs.2019.104446 34486233 RAZ_Lanisnik-Rizner_Tea_2020.pdf RAZ_Lanisnik-Rizner_Tea_2020.pdf 1 43017A1204C6323E3D06E2DF35B1770D 132a2c37dd161f3adc0a26588518982596463ffa332b9047e43a076f9e4836ba c6c0db47-efa1-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145651 https://www.sciencedirect.com/science/article/pii/S1043661819314732 1 947f3599-efa1-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145650 Medicinska fakulteta 0 0 0