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Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice
ID Markova, Liljana (Avtor), ID Umek, Nejc (Avtor), ID Horvat, Simon (Avtor), ID Hadžić, Admir (Avtor), ID Kuroda, Maxine M. (Avtor), ID Stopar Pintarič, Tatjana (Avtor), ID Mrak, Vesna (Avtor), ID Cvetko, Erika (Avtor)

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Izvleček
Background: Long-acting local anaesthetics (e.g. bupivacaine hydrochloride) or sustained-release formulations of bupivacaine (e.g. liposomal bupivacaine) may be neurotoxic when applied in the setting of diabetic neuropathy. The aim of the study was to assess neurotoxicity of bupivacaine and liposome bupivacaine in streptozotocin (STZ) - induced diabetic mice after sciatic nerve block. We used the reduction in fibre density and decreased myelination assessed by G-ratio (defined as axon diameter divided by large fibre diameter) as indicators of local anaesthetic neurotoxicity. Results: Diabetic mice had higher plasma levels of glucose (P < 0.001) and significant differences in the tail flick and plantar test thermal latencies compared to healthy controls (P < 0.001). In both diabetic and nondiabetic mice, sciatic nerve block with 0.25% bupivacaine HCl resulted in a significantly greater G-ratio and an axon diameter compared to nerves treated with 1.3% liposome bupivacaine or saline (0.9% sodium chloride) (P < 0.01). Moreover, sciatic nerve block with 0.25% bupivacaine HCl resulted in lower fibre density and higher large fibre and axon diameters compared to the control (untreated) sciatic nerves in both STZ-induced diabetic (P < 0.05) and nondiabetic mice (P < 0.01). No evidence of acute or chronic inflammation was observed in any of the treatment groups. Conclusions: In our exploratory study the sciatic nerve block with bupivacaine HCl (7 mg/kg), but not liposome bupivacaine (35 mg/kg) or saline, resulted in histomorphometric indices of neurotoxicity. Histologic findings were similar in diabetic and healthy control mice.

Jezik:Angleški jezik
Ključne besede:bupivacaine hydrochloride, diabetes, neurotoxicity, liposome bupivacaine injectable suspension, peripheral neuropathy
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:8 str.
Številčenje:Vol. 16, art. 247
PID:20.500.12556/RUL-128775 Povezava se odpre v novem oknu
UDK:615.2
ISSN pri članku:1746-6148
DOI:10.1186/s12917-020-02459-4 Povezava se odpre v novem oknu
COBISS.SI-ID:23004675 Povezava se odpre v novem oknu
Datum objave v RUL:28.07.2021
Število ogledov:1076
Število prenosov:228
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Gradivo je del revije

Naslov:BMC veterinary research
Založnik:BioMed Central.
ISSN:1746-6148
COBISS.SI-ID:515674393 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:17.07.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:bupivakain hidroklorid, diabetes, nevrotoksičnost, injicirana suspenzija liposomskega bupivakaina, periferalna nevropatija

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0043
Naslov:Molekularni mehanizmi razvoja in delovanja skeletne mišice

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P4-0220
Naslov:Primerjalna genomika in genomska biodiverziteta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Clinical Department of Anaesthesiology and Intensive Therapy, University Clinical Centre (Ljubljana, Slovenia); tertiary funding

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