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The pore-forming action of polyenes : from model membranes to living organisms
ID Kristanc, Luka (Author), ID Božič, Bojan (Author), ID Zemljič Jokhadar, Špela (Author), ID Sollner Dolenc, Marija (Author), ID Gomišček, Gregor (Author)

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Abstract
The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.

Language:English
Keywords:polyenes, sterols, pore-forming, tension pore, osmotic stress
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
FFA - Faculty of Pharmacy
ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Year:2019
Number of pages:Str. 418-430
Numbering:Vol. 1861, iss. 2
PID:20.500.12556/RUL-128754 This link opens in a new window
UDC:579+616
ISSN on article:0005-2736
DOI:10.1016/j.bbamem.2018.11.006 This link opens in a new window
COBISS.SI-ID:4634737 This link opens in a new window
Publication date in RUL:27.07.2021
Views:1652
Downloads:216
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Record is a part of a journal

Title:Biochimica et biophysica acta. Biomembranes
Shortened title:Biochim. biophys. acta, Biomembr.
Publisher:Elsevier
ISSN:0005-2736
COBISS.SI-ID:4077101 This link opens in a new window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:01.02.2019

Secondary language

Language:Slovenian
Keywords:polieni, steroli, tvorjenje por, tenzijska pora, osmotski stres

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0055
Name:Biofizika polimerov, membran, gelov, koloidov in celic

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