20.500.12556/RUL-128754 The pore-forming action of polyenes from model membranes to living organisms The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells. polyenes sterols pore-forming tension pore osmotic stress polieni steroli tvorjenje por tenzijska pora osmotski stres true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-27 14:21:37 2021-07-27 14:21:41 2022-09-07 04:16:59 0000-00-00 00:00:00 2019 0 0 Str. 418-430 iss. 2 Vol. 1861 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579+616 0005-2736 10.1016/j.bbamem.2018.11.006 4634737 RAZ_Kristanc_Luka_2019.pdf RAZ_Kristanc_Luka_2019.pdf 1 BCDA1E453141A00451B78F690D2BF526 1648e9ebd1e42855b84fe8b6f51b6c7ec85ea4398a637dfd6d75d8fbd9891513 345b28e7-eed5-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145609 https://www.sciencedirect.com/science/article/pii/S0005273618303444 1 07b19936-eed5-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145608 Medicinska fakulteta Fakulteta za farmacijo Zdravstvena fakulteta 0 0 0