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The use of polymer chitosan in intravesical treatment of urinary bladder cancer and infections
Erman, Andreja (Author), Veranič, Peter (Author)

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Abstract
The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50-80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis.

Language:English
Keywords:chitosan, biological activity, medical applications
Work type:Article (dk_c)
Tipology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Year:2018
Number of pages:10 str.
Numbering:Vol. 10, iss. 3, art. 265
UDC:577
ISSN on article:2073-4360
DOI:10.3390/polym10030265 This link opens in a new window
COBISS.SI-ID:33675993 This link opens in a new window
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Record is a part of a journal

Title:Polymers
Shortened title:Polymers
Publisher:Molecular Diversity Preservation International
ISSN:2073-4360
COBISS.SI-ID:517951257 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P3-0108
Name:Diferenciacija urotelijskih celic

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:05.03.2018

Secondary language

Language:Slovenian
Keywords:hitozan, biološka dejavnost, medicinske aplikacije

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