The use of polymer chitosan in intravesical treatment of urinary bladder cancer and infections

Erman, Andreja (author), Veranič, Peter (author)

The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50-80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis.

• Language: English
• Keywords: chitosan, biological activity, medical applications
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2018
• Number of pages: 10 str.
• Numbering: Vol. 10, iss. 3, art. 265
• PID: 20.500.12556/RUL-128739
• UDC: 577
• ISSN on article: 2073-4360
• DOI: 10.3390/polym10030265
• COBISS.SI-ID: 33675993

Note

V datoteki založnikove različice članka (PDF) je navedena napačna številka članka (625). Prava številka članka (265) je navedena na pristajalni strani članka (URL). (Datum opombe: 28. 7. 2021)

• Publication date in RUL: 27.07.2021

Record is a part of a journal

• Title: Polymers
• Shortened title: Polymers
• Publisher: MDPI
• ISSN: 2073-4360
• COBISS.SI-ID: 517951257

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 05.03.2018

Secondary language

• Language: Slovenian
• Keywords: hitozan, biološka dejavnost, medicinske aplikacije

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0108
• Name: Diferenciacija urotelijskih celic