The use of polymer chitosan in intravesical treatment of urinary bladder cancer and infections

Erman, Andreja (avtor), Veranič, Peter (avtor)

The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50-80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis.

• Jezik: Angleški jezik
• Ključne besede: chitosan, biological activity, medical applications
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2018
• Št. strani: 10 str.
• Številčenje: Vol. 10, iss. 3, art. 265
• PID: 20.500.12556/RUL-128739
• UDK: 577
• ISSN pri članku: 2073-4360
• DOI: 10.3390/polym10030265
• COBISS.SI-ID: 33675993

Opomba

V datoteki založnikove različice članka (PDF) je navedena napačna številka članka (625). Prava številka članka (265) je navedena na pristajalni strani članka (URL). (Datum opombe: 28. 7. 2021)

• Datum objave v RUL: 27.07.2021

Gradivo je del revije

• Naslov: Polymers
• Skrajšan naslov: Polymers
• Založnik: Molecular Diversity Preservation International
• ISSN: 2073-4360
• COBISS.SI-ID: 517951257

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 05.03.2018

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: hitozan, biološka dejavnost, medicinske aplikacije

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0108
• Naslov: Diferenciacija urotelijskih celic