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Proučevanje sestave kozmetičnih izdelkov z niacinamidom
ID Majar, Katja (Author), ID Ahlin Grabnar, Pegi (Mentor) More about this mentor... This link opens in a new window, ID Bjelošević, Maja (Comentor)

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Abstract
Trend razvoja kozmetičnih izdelkov (KI) je aktivna nega. Izbrane kozmetično aktivne sestavine (KAS) v koži stimulirajo celice in mehanizme, ki pripomorejo k temu, da koža čim dlje ostane gladka, napeta in voljna in tako aktivno posegajo v delovanje kože. Medtem ko številne druge KAS na trgu doživljajo svoje vzpone in padce, so vitamini še vedno stalnica v razvoju KI. Niacinamid je vodotopna oblika vitamina B, ki se uporablja v različnih tehnoloških oblikah, od krem za nego kože, do serumov. V diplomski nalogi smo raziskali sestavo in delovanje 48-ih KI z niacinamidom. Zanimalo nas je, v katerih tehnoloških oblikah se niacinamid pojavlja, njegova koncentracija ter namen uporabe izbranih KI, predvideno mesto nanosa, mehanizmi delovanja pri posamezni kožni nepravilnosti, ter ostale KAS in njihova vloga v KI z niacinamidom. Na koncu smo preverili tudi ceno ter oglaševanje izbranih KI. KI z niacinamidom so se pojavljali v večih različnih tehnoloških oblikah, med katerimi so izstopali serumi (42 %) in hidrofilne kreme (38 %) za nego obraza, vratu in dekolteja. Niacinamid je v serumih KAS, ki zavira nastanek reaktivnih kisikovih spojin (ROS) in učinkovito gladi gube. Podatka o koncentraciji niacinamida pri večini izdelkov (83 %) nismo našli. Za nego aknaste, hiperpigmentirane ali zrele kože je zadostna koncentracija niacinamida 5 %. Niacinamid se je največkrat pojavljal v »anti-age« KI (29 %), kjer kot del koencimov NAD in NADP pripomore k zmanjšanju oksidativnega stresa v koži. 10 izdelkov (21 %) z niacinamidom je bilo namenjenih negi aknaste kože, kjer sposobnost niacinamida, da uravnava nastanek sebuma, pomaga preprečiti izbruhe aken, zlasti pri ljudeh z mastno kožo. Proučili smo tudi kombinacijo niacinamida in cinkovih soli (17 %). Naloga cinkovih soli v kombinaciji z niacinamidom je, da pomagajo normalizirati nastanek sebuma in omejiti širjenje bakterij, ki povzročajo akne. Preverili smo tudi, katere druge KAS poleg niacinamida se pojavljajo v izbranih KI. Največkrat so bili prisotni natrijev hialuronat (29 %) in drugi vitamini skupine B (31 %), največkrat pantenol, torej predstavniki vlažil in antioksidantov (AO), ki imajo pomembno vlogo pri negi suhe kože in kože, nagnjene k staranju. Izbrani izdelki so bili upoštevajoč ceno podobno uvrščeni v višji (54 %) in nižji (46 %) cenovni razred. Ugotovili smo tudi, da 19 % izbranih izdelkov niacinamid oglašuje z imenom vitamin B3, 81 % izdelkov pa z imenom niacinamid. Zaključimo lahko, da je niacinamid vitamin z velikim potencialom in možnostjo uporabe v kozmetiki zaradi svoje varnosti in širokospektralnega delovanja.

Language:Slovenian
Keywords:Niacinamid, vitamin B3, kozmetični izdelek, nega
Work type:Bachelor thesis/paper
Organization:FFA - Faculty of Pharmacy
Year:2021
PID:20.500.12556/RUL-128301 This link opens in a new window
Publication date in RUL:08.07.2021
Views:1147
Downloads:179
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Secondary language

Language:English
Title:A study of composition of niacinamide containing cosmetic products
Abstract:
The trend in the development of cosmetic products (CP) is active care. Selected cosmetically active ingredients (CAI) actively interfere with the functioning of the skin and stimulate in it cells and mechanisms responsible for keeping the skin smooth, tight and supple for as long as possible. While other CAIs that are used in the market experience their ups and downs, vitamins are still a constant in the development of CPs. Niacinamide is a water-soluble form of vitamin B that is used in all technological forms, from skin care creams to serums. In the diploma thesis, we researched the composition and function of 48 CPs with niacinamide. We were interested in the technological forms in which niacinamide occurs, its concentration and purpose of use of selected CPs, intended site of application, mechanisms of action in individual skin abnormalities, and other CAIs and their role in CPs with niacinamide. We also checked the price and advertising of other selected CPs. CPs with niacinamide occurred in several technological forms, where serums (42 %) and hydrophilic creams (38 %) for face, neck and decolletage care stood out. Niacinamide is the CAI in serums, which most often inhibits the formation of reactive oxygen species (ROS) and effectively smooths wrinkles. No data on niacinamide concentration were found in most products (83 %). For the care of acne-prone, hyperpigmented or mature skin, a concentration of 5 % niacinamide is sufficient. Niacinamide most often appeared in »anti-age« CPs (29 %), where as part of the coenzymes NAD and NADP it helps to reduce oxidative stress in the skin. 10 products (21 %) with niacinamide were intended for care of acne-prone skin, where the ability of niacinamide to regulate sebum production helps to prevent acne outbreaks, especially for people with oily skin. We also studied the combination of niacinamide and zinc salts (17 %). The function of zinc salts in combination with niacinamide is to help normalize and limit the spread of acne-causing bacteria. We also examined which other CAIs appear in addition to niacinamide in selected CPs and found that sodium hyaluronate (29 %) and other B-complex vitamins (31 %), most commonly panthenol, occur very frequently. Among all, the most represented are moisturizers and antioxidants (AO), which play an important role in the care of dry skin and skin prone to aging. Selected products were similarly classified in the higher (54 %) and lower (46 %) price range. We also found that 19 % of selected products advertise niacinamide with the name vitamin B3, and 81 % of products with the name niacinamide. We can conclude that niacinamide is a vitamin with great potential and the possibility of use in cosmetics, due to its safety and broad-spectrum action.

Keywords:Niacinamide, vitamin B3, cosmetic product, skin care

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