Polyphenols from food and natural products : neuroprotection and safety
ID Silva, Rui F. M. (Author), ID Pogačnik da Silva, Lea (Author)

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Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions connected to oxidative stress and inflammation (e.g., cancer, and cardiovascular and neurodegenerative disorders). Neurodegenerative diseases are globally one of the main causes of death and represent an enormous burden in terms of human suffering, social distress, and economic costs. Recent data expanded on the initial antioxidant-based mechanism of polyphenols’ action by showing that they are also able to modulate several cell-signaling pathways and mediators. The proposed benefits of polyphenols, either as protective/prophylactic substances or as therapeutic molecules, may be achieved by the consumption of a natural polyphenol-enriched diet, by their use as food supplements, or with formulations as pharmaceutical drugs/nutraceuticals. It has also been proved that the health effects of polyphenols depend on the consumed amount and their bioavailability. However, their overconsumption may raise safety concerns due to the accumulation of high levels of these molecules in the organism, particularly if we consider the loose regulatory legislation regarding the commercialization and use of food supplements. This review addresses the main beneficial effects of food polyphenols, and focuses on neuroprotection and the safety issues related to overconsumption.

Keywords:bioavailability, in vitro models, neuroprotection, neurotoxicity, polyphenols, toxicity
Work type:Article
Typology:1.02 - Review Article
Organization:BF - Biotechnical Faculty
Publication status:Published
Publication version:Version of Record
Number of pages:13 str.
Numbering:Vol. 9, iss. 1, art. 61
PID:20.500.12556/RUL-128260 This link opens in a new window
ISSN on article:2076-3921
DOI:10.3390/antiox9010061 This link opens in a new window
COBISS.SI-ID:5147512 This link opens in a new window
Publication date in RUL:07.07.2021
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Shortened title:Antioxidants
COBISS.SI-ID:522976025 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:10.01.2020

Secondary language

Keywords:živila, fenolne spojine, polifenoli, bioaktivne snovi, nevroprotektivne snovi


Funder:Other - Other funder or multiple funders
Funding programme:iMed.ULisboa

Funder:FCT - Fundação para a Ciência e a Tecnologia, I.P.
Funding programme:5876
Project number:147348
Name:Research Institute for Medicines

Funder:ARRS - Slovenian Research Agency
Project number:P4-0121
Name:Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi

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