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Polyphenols from food and natural products : neuroprotection and safety
ID
Silva, Rui F. M.
(
Avtor
),
ID
Pogačnik da Silva, Lea
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,05 MB)
MD5: E515184FA02D7D45B0E56192FB35D2E7
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-3921/9/1/61
Galerija slik
Izvleček
Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions connected to oxidative stress and inflammation (e.g., cancer, and cardiovascular and neurodegenerative disorders). Neurodegenerative diseases are globally one of the main causes of death and represent an enormous burden in terms of human suffering, social distress, and economic costs. Recent data expanded on the initial antioxidant-based mechanism of polyphenols’ action by showing that they are also able to modulate several cell-signaling pathways and mediators. The proposed benefits of polyphenols, either as protective/prophylactic substances or as therapeutic molecules, may be achieved by the consumption of a natural polyphenol-enriched diet, by their use as food supplements, or with formulations as pharmaceutical drugs/nutraceuticals. It has also been proved that the health effects of polyphenols depend on the consumed amount and their bioavailability. However, their overconsumption may raise safety concerns due to the accumulation of high levels of these molecules in the organism, particularly if we consider the loose regulatory legislation regarding the commercialization and use of food supplements. This review addresses the main beneficial effects of food polyphenols, and focuses on neuroprotection and the safety issues related to overconsumption.
Jezik:
Angleški jezik
Ključne besede:
bioavailability
,
in vitro models
,
neuroprotection
,
neurotoxicity
,
polyphenols
,
toxicity
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
13 str.
Številčenje:
Vol. 9, iss. 1, art. 61
PID:
20.500.12556/RUL-128260
UDK:
547.9:641.1:547.56:616.8
ISSN pri članku:
2076-3921
DOI:
10.3390/antiox9010061
COBISS.SI-ID:
5147512
Datum objave v RUL:
07.07.2021
Število ogledov:
1744
Število prenosov:
235
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Antioxidants
Skrajšan naslov:
Antioxidants
Založnik:
MDPI
ISSN:
2076-3921
COBISS.SI-ID:
522976025
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
10.01.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
živila
,
fenolne spojine
,
polifenoli
,
bioaktivne snovi
,
nevroprotektivne snovi
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
iMed.ULisboa
Financer:
FCT - Fundação para a Ciência e a Tecnologia, I.P.
Program financ.:
5876
Številka projekta:
147348
Naslov:
Research Institute for Medicines
Akronim:
UID/DTP/04138/2013
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0121
Naslov:
Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi
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