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Bacterial adhesion capacity of uropathogenic Escherichia coli to polyelectrolyte multilayer coated urinary catheter surface
ID Bohinc, Klemen (Author), ID Kukić, Lora (Author), ID Štukelj, Roman (Author), ID Zore, Anamarija (Author), ID Abram, Anže (Author), ID Klačić, Tin (Author), ID Kovačević, Davor (Author)

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Abstract
The application of catheters to the urinary tract is associated with nosocomial infections. Such infections are one of the most common types of infections in hospitals and health care facilities and can lead to numerous medical complications. Therefore, the understanding of the properties of urinary catheter surfaces and their potential modifications are crucial in order to reduce bacterial adhesion and subsequent biofilm formation. In our study, we consider standard polyvinyl chloride (PVC) catheter surfaces and compare their properties with the properties of the same surfaces coated with poly(diallyldimethylammonium chloride)/poly(sodium 4-styrenesulfonate) (PDADMA/PSS) polyelectrolyte multilayers. Uncoated and coated surfaces were characterized by means of roughness, hydrophobicity, and zeta potential measurements. Finally, bacterial adhesion extent of uropathogenic Escherichia coli on bare and polyelectrolyte multilayer coated surfaces was measured. The obtained results show that on non-treated surfaces, biofilm is formed which was not the case for multilayer coated surfaces. The PSS-terminated multilayer shows the lowest bacterial adhesion and could be helpful in prevention of biofilm formation. The analysis of the properties of the uncoated and coated surfaces reveals that the most significant difference is related to the charge (i.e., zeta potential) of the examined surfaces, while roughness and hydrophobicity of the examined surfaces are similar. Therefore, it could be concluded that the surface charge plays the crucial role in the bacterial adhesion on uncoated and coated PVC catheter surfaces.

Language:English
Keywords:urinary catheters, polyelectrolyte multilayers, bacterial adhesion, Escherichia coli
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:12 str.
Numbering:Vol. 11, iss. 6, art. 630
PID:20.500.12556/RUL-127243 This link opens in a new window
UDC:544.722.54:615.472.5
ISSN on article:2079-6412
DOI:10.3390/coatings11060630 This link opens in a new window
COBISS.SI-ID:64997379 This link opens in a new window
Publication date in RUL:28.05.2021
Views:886
Downloads:188
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Record is a part of a journal

Title:Coatings
Shortened title:Coatings
Publisher:MDPI AG
ISSN:2079-6412
COBISS.SI-ID:523035673 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.06.2021

Projects

Funder:ARRS - Slovenian Research Agency
Project number:J7-2595
Name:Modulacija polifenolnega profila v sadju s trajnostnimi fizikalnimi poobiralnimi postopki

Funder:HRZZ - Croatian Science Foundation
Project number:IPS-2020-01-6126

Funder:ARRS - Slovenian Research Agency
Project number:P3-0388
Name:Mehanizmi varovanja zdravja

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