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Sistematični pregled izsledkov raziskav o vlogi vitamina D pri COVID-19
ID Gjorgievska, Nataša (Avtor), ID Mravljak, Janez (Mentor) Več o mentorju... Povezava se odpre v novem oknu

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Izvleček
Ozadje: Zaradi pandemije koronavirusne bolezni 2019 (COVID-19), so začeli raziskovalci bolj intenzivno raziskovati imunomodulatorno funkcijo vitamina D. Raziskovalci so predlagali, da lahko citokinsko nevihto, ki prihaja z resnostjo bolezni in njenimi posledicami, zmanjšamo ali celo preprečimo z vsakodnevno uporabo vitamina D. Novi koronavirus vstopi v gostiteljsko celico s pritrditvijo na receptor angiotenzinske konvertaze tipa 2 in tako poškoduje pljučne celice. V tem koraku lahko vitamin D igra pomembno vlogo, saj spodbuja izražanje tega receptorja. Z dodatkom vitamina D se lahko zmanjša poškodbe pljučnega tkiva, ki je posledica zapletov pri okužbi s SARS-CoV-2. Namen dela: Namen izdelave magistrske naloge je proučitev vpliva koncentracije vitamina D v krvi na verjetnost okužbe z virusom SARS-CoV-2, potek oz. resnost bolezni COVID-19 in vpliv dodatek vitamina D na potek bolezni. Metode: Izvedli smo sistematični pregled izsledkov raziskav o vlogi vitamina D pri COVID-19. Opravljene raziskave smo iskali v bazah podatkov PUBMED, Web of Science in Google Učenjak. Izbor je bil izveden s pomočjo vključitvenih in izključitvenih kriterijev, v skladu s smernicami PRISMA. Izbrali smo raziskave, izvedene leta 2020, ki so vključevale podatke o koncentracijah vitamina D pred, med in/ali po okužbi z novim koronavirusom in ki so svoje podatke primerjale z verjetnostjo okužbe s SARS-CoV-2 ter resnostjo bolezni. Vključili smo tudi nekaj raziskav, v katerih so proučevali učinek vitamina D kot podpornega zdravljenja COVID-19. Rezultati: V skladu s smernicami PRISMA smo izbrali 27 raziskav, ki so izpolnjevale naša merila za vključitev. Najprej smo naredili analizo raziskav po državi, v kateri so bile izvedene, po mesecu objave, številu udeležencev in načrtu študije. Nato smo predstavili glavne značilnosti vsake raziskave, vključno s povezavo med vitaminom D in verjetnostjo okužbe, resnostjo bolezni in učinkom dodajanja dnevnih ali bolusnih odmerkov vitamina D. Pri večini preiskovancev, vključenih v raziskave, so ugotovili povezanost med pomanjkanjem vitamina D ali hipovitaminozo D ter verjetnostjo okužbe in resnostjo bolezni. Ugotovili so, da imata tako dnevni kot bolusni dodatek vitamina D vpliv na potek COVID-19, s poudarkom na boljših rezultatih dnevnih nižjih odmerkov. Sklep: Rezultati raziskav poročajo, da obstaja povezava med koncentracijo vitamina D v krvi in kliničnimi izidi bolezni COVID-19. Dodatek vitamina D je možna izbira za preprečevanje COVID-19. Njegov vpliv in koristi pa je treba za kvantitativne rezultate preučiti z dodatnimi, obsežnimi, randomizianimi kliničnimi raziskavami.

Jezik:Slovenski jezik
Ključne besede:vitamin D, COVID-19, SARS-CoV-2
Vrsta gradiva:Magistrsko delo/naloga
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2021
PID:20.500.12556/RUL-125998 Povezava se odpre v novem oknu
Datum objave v RUL:11.04.2021
Število ogledov:1138
Število prenosov:408
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Sekundarni jezik

Jezik:Angleški jezik
Naslov:Systematic review of research results/outcomes on the role of vitamin D in COVID-19
Izvleček:
Background: Due to the coronavirus disease 2019 (COVID-19) pandemic, researchers began to investigate the immunomodulatory function of vitamin D more intensively. Researchers suggested that the cytokine storm, that comes with the disease severity and its consequences can be reduced or even prevented with the daily use of vitamin D. The new coronavirus enters the host cell by attaching to the angiotensin converting enzyme 2 receptor and thus damaging lung cells. Vitamin D can play an important role in this step, as it stimulates the expression of the receptor and thus reduces lung cells damage because of SARS-CoV-2. Aim: The purpose of this master's thesis is to study the effect of the concentration of vitamin D in the blood on the likelihood of infection with the SARS-CoV-2 virus, the course or severity of COVID-19 disease and the effect of vitamin D supplementation on the course of the disease. Methods: We performed a systematic review of research results on the role of vitamin D in COVID-19. PUBMED, Web of Science and Google Scholar were the databases where we were searching for the studies made. The selection was carried out using an inclusion and exclusion criteria, in accordance with the PRISMA guidelines. We selected studies conducted in 2020 that included data on vitamin D levels in blood before, during and/or after infection with the novel coronavirus and that compared their data with the likelihood of SARS-CoV-2 infection and disease severity. We also included some studies examining the effect of vitamin D as a supportive treatment for COVID-19. Results: In accordance with the PRISMA guidelines, we selected 27 studies that met our inclusion criteria. We first made analysis of the studies by country, in which they were conducted, by the month of publication, number of participants and design of the study. We than presented the main features of each study, including the association between the vitamin D and the likelihood of infection, disease severity and the effect of adding daily or bolus doses of vitamin D. Deficit or hypovitaminosis was found in the most patients included in the studies, which was linked with the likelihood of infection and disease severity. Both, daily and bolus supplementation were found to influence the course of COVID-19, with the emphasis on daily lower doses. Conclusion: The results report that there is an association between vitamin D levels in the blood and COVID-19. Vitamin D is a possible choice to prevent COVID-19. Its impact and benefits, however, need to be examined for quantitative results through additional, extensive, randomized clinical trials.

Ključne besede:vitamin D, COVID-19, SARS-CoV-2

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