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Effect of solution composition variables on electrospun alginate nanofibers : response surface analysis
ID Mirtič, Janja (Author), ID Balažic, Helena (Author), ID Zupančič, Špela (Author), ID Kristl, Julijana (Author)

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Abstract
Alginate is a promising biocompatible and biodegradable polymer for production of nanofibers for drug delivery and tissue engineering. However, alginate is difficult to electrospin due to its polyelectrolyte nature. The aim was to improve the 'electrospinability' of alginate with addition of exceptionally high molecular weight poly(ethylene oxide) (PEO) as a co-polymer. The compositions of the polymer-blend solutions for electrospinning were varied for PEO molecular weight, total (alginate plus PEO) polymer concentration, and PEO proportion in the dry alginate PEO polymer mix used. These were tested for rheology (viscosity, complex viscosity, storage and loss moduli) and conductivity, and the electrospun nanofibers were characterized by scanning electron microscopy. One-parameter-at-a-time approach and response surface methodology (RSM) were used to optimize the polymer-blend solution composition to obtain defined nanofibers. Both approaches revealed that the major influence on nanofiber formation and diameter were total polymer concentration and PEO proportion. These polymer-blend solutions of appropriate conductivity and viscosity enabled fine-tuning of nanofiber diameter. PEO molecular weight of 2-4 million Da greatly improved the electrospinnability of alginate, producing nanofibers with >85% alginate. This study shows that RSM can be used to design nanofibers with optimal alginate and co-polymer contents to provide efficient scaffold material for regenerative medicine.

Language:English
Keywords:nanofibers, electrospinning, alginate, polyethylene oxide, conductivity, viscoelastic properties, response surface methodology
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Publication status:Published
Publication version:Version of Record
Year:2019
Number of pages:20 str.
Numbering:Vol. 11, iss. 4, art. 692
PID:20.500.12556/RUL-125361 This link opens in a new window
UDC:66.017-022.513.2:620.3
ISSN on article:2073-4360
DOI:10.3390/polym11040692 This link opens in a new window
COBISS.SI-ID:4704625 This link opens in a new window
Publication date in RUL:12.03.2021
Views:923
Downloads:252
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Record is a part of a journal

Title:Polymers
Shortened title:Polymers
Publisher:Molecular Diversity Preservation International
ISSN:2073-4360
COBISS.SI-ID:517951257 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:12.03.2021

Secondary language

Language:Slovenian
Keywords:nanovlakna, elektrospiniranje, alginat, polietilen oksid, prevodnost, viskoelastične lastnosti, metodologija odzivne površine

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

Funder:ARRS - Slovenian Research Agency
Project number:J1-9194
Name:Nanozdravila z antibiotiki in probiotiki za lokalno zdravljenje parodontalne bolezni

Funder:ARRS - Slovenian Research Agency
Project number:J4-7640
Name:Elektrostatska imobilizacija bakterij in vpliv na njihovo fiziologijo

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