Nitrosative stress in the frontal cortex from dogs with canine cognitive dysfunction
Prpar Mihevc, Sonja (Author), Zakošek, Maja (Author), Štrbenc, Malan (Author), Rogelj, Boris (Author), Majdič, Gregor (Author)

URLURL - Source URL, Visit https://www.frontiersin.org/articles/10.3389/fvets.2020.573155/full This link opens in a new window

Canine cognitive dysfunction (CCD) is an age-related disorder similar to human Alzheimer's disease (AD) that occurs in elderly dogs. Nitrosative stress has been implicated as one of the causes leading to neurodegenerative diseases, particularly AD. Its involvement in the development of CCD has not been studied so far. In the present study, immunohistochemical staining detected all three isoforms of nitric oxide synthases (nNOS, eNOS, and iNOS) and 3-nitrotyrosine (3-NT) in brains from CCD-affected dogs and non-demented control dogs in all layers of the canine frontal cortex. In CCD-affected and non-demented brains, nNOS was highly expressed in pyramidal-like neurons in the upper cortical layers. nNOS has also been observed in astrocytes in the CCD frontal cortex. The nNOS immunohistochemical staining was statistically significantly elevated in dogs with CCD in comparison to non-demented dogs. Blood vessel wall cells were positive for eNOS, which was also expressed in astrocytes and neurons. Intense 3-NT immunoreactivity was observed in the upper cortical layers, where amyloid-beta deposits spread in the last stage of CCD. Brain cells in the same area were highly immunoreactive for iNOS. This infers that neuroinflammation and nitrosative stress might exacerbate the neurodegenerative process in CCD-affected brains, ultimately leading to cognitive impairment

Keywords:Canine cognitive dysfunction, nitrosative stress, nNOS, eNOS, iNOS, 3-nitrotyrosine
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:VF - Veterinary Faculty
Number of pages:art. 573155, str. 1-14
Numbering:Vol. 7
ISSN on article:2297-1769
DOI:10.3389/fvets.2020.573155 This link opens in a new window
COBISS.SI-ID:38304259 This link opens in a new window
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Record is a part of a journal

Title:Frontiers in veterinary science
Shortened title:Front. vet. sci.
Publisher:Frontiers Media S.A.
COBISS.SI-ID:3969402 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Funding Programme:Evropski sklad za regionalni razvoj, Raziskovalci na začetku kariere 2.0
Project no.:P4-0053
Name:Razvoj in uporaba naprednih celičnih terapij za zdravljenje demence pri psih


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:19.11.2020

Secondary language

Keywords:Pasja kognitivna motnja, nitrozativni stres, nNOS, eNOS, iNOS, 3-nitrotirozin

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