Aripiprazole reduces liver cell division : research data underlying the article

Pirc Marolt, Tinkara (author), Kramar, Barbara (author), Bulc Rozman, Klara (author), Šuput, Dušan (author), Milisav, Irina (author)

Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patients’ serum, reduce the rate of hepatocytes’ division. This could be an underlying mechanism of severe liver injury development in the patients with a history of alcohol and cocaine abuse, the two hepatotoxic agents that require increased ability of liver self-regeneration. Monitoring liver functions is, therefore, important in the cases when aripiprazole is co-prescribed or used with drugs with potential hepatotoxic effects.

• Language: English
• Keywords: Aripiprazole, Olanzapine, chemical and drug induced liver injury, antipsychotics, second-generation antipsychotics
• Organization: MF - Faculty of Medicine
• Place of publishing: Ljubljana
• Year: 2020
• PID: 20.500.12556/RUL-121367
• Publication date in RUL: 06.10.2020

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0019
• Name: Aplikativna in bazična fiziologija in patofiziologija v medicini

• Funder: EC - European Commission
• Funding programme: H2020
• Project number: 721236
• Name: Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
• Acronym: TREATMENT