20.500.12556/RUL-121367 Aripiprazole reduces liver cell division research data underlying the article Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patients’ serum, reduce the rate of hepatocytes’ division. This could be an underlying mechanism of severe liver injury development in the patients with a history of alcohol and cocaine abuse, the two hepatotoxic agents that require increased ability of liver self-regeneration. Monitoring liver functions is, therefore, important in the cases when aripiprazole is co-prescribed or used with drugs with potential hepatotoxic effects. Aripiprazole Olanzapine chemical and drug induced liver injury antipsychotics second-generation antipsychotics true false false Angleški jezik Ni določen Neznano 2020-10-06 14:35:14 2020-10-06 14:36:26 2025-04-16 12:45:01 0000-00-00 00:00:00 2020 0 Ljubljana 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 Data_for_article_Aripiprazole_reduces_liver_cell_division.xlsx Data_for_article_Aripiprazole_reduces_liver_cell_division.xlsx 1 ADFCEB8D30EF86405F550AE0068B3C29 77b19bb32a719180122b39ca5fe2c34737bb3959eacf6c0cd3ea16db9b5e5823 df76b054-a1ba-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=136285 Medicinska fakulteta 0 0 0