The use of fluorine atoms in pharmaceutical and agrochemical products has greatly increased in recent years due to the unique properties of the fluorine atom. Of special interest for use in pharmaceuticals are compounds containing trifluoromethyl group. As a result, the chemistry of fluorinated organic compounds has flourished, and interest in the development of new methods of direct trifluoromethylation and new trifluoromethylation reagents has increased. In my thesis I presented nucleophilic trifluoromethylation with Ruppert-Prakash reagent and various other nucleophilic reagents and initiators, electrophilic trifluoromethylation using Togni and Umemoto reagents and radical trifluoromethylation.
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