Preliminary toxicokinetic study of BPA in lactating dairy sheep after repeated dietary and subcutaneous administration

Šturm, Sabina (author), Grabnar, Iztok (author), Škibin, Andrej (author), Pogačnik, Milan (author), Cerkvenik, Vesna (author)

Dietary intake is the predominant route of human exposure to bisphenol A and one of the important food commodities is milk. the aim of our study was to preliminarily evaluate the bisphenol A exposure and disposition in sheep milk after repeated dietary and subcutaneous administration of a relatively low dose (100 μg/kg of b. w./day) of bisphenol A to a sheep. on the basis of blood plasma sampling, milk sampling and HpLc analysis, we developed the toxicokinetic model. With the toxicokinetic model we showed that most likely only free bisphenol A passes into the mammary gland and is subsequently conjugated there. the percentage of the dose eliminated with milk was less than 0.1%, regardless of the route of bisphenol A administration. It is proven that the bisphenol A is eliminated through the milk of lactating sheep. However, the amounts excreted in the milk that were detected in this study are minimal.

• Language: English
• Keywords: toxicology, bisphenols A - pharmacokinetics - toxicity, sheep
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty; FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 9 str.
• Numbering: Vol. 10, art. 6498
• PID: 20.500.12556/RUL-118010
• UDC: 636.3.09:615.9
• ISSN on article: 2045-2322
• DOI: 10.1038/s41598-020-63286-z
• COBISS.SI-ID: 5111162
• Publication date in RUL: 11.08.2020

Record is a part of a journal

• Title: Scientific reports
• Shortened title: Sci. rep.
• Publisher: Nature Publishing Group
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 16.04.2020

Secondary language

• Language: Slovenian
• Keywords: toksikologija, bisfenoli A - farmakokinetika - toksičnost, ovce

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0092
• Name: Zdravje živali, okolje in varna hrana

• Funder: ARRS - Slovenian Research Agency
• Funding programme: Postgraduate (Ph.D.) research funding