Preliminary toxicokinetic study of BPA in lactating dairy sheep after repeated dietary and subcutaneous administration

Šturm, Sabina (avtor), Grabnar, Iztok (avtor), Škibin, Andrej (avtor), Pogačnik, Milan (avtor), Cerkvenik, Vesna (avtor)

Dietary intake is the predominant route of human exposure to bisphenol A and one of the important food commodities is milk. the aim of our study was to preliminarily evaluate the bisphenol A exposure and disposition in sheep milk after repeated dietary and subcutaneous administration of a relatively low dose (100 μg/kg of b. w./day) of bisphenol A to a sheep. on the basis of blood plasma sampling, milk sampling and HpLc analysis, we developed the toxicokinetic model. With the toxicokinetic model we showed that most likely only free bisphenol A passes into the mammary gland and is subsequently conjugated there. the percentage of the dose eliminated with milk was less than 0.1%, regardless of the route of bisphenol A administration. It is proven that the bisphenol A is eliminated through the milk of lactating sheep. However, the amounts excreted in the milk that were detected in this study are minimal.

• Jezik: Angleški jezik
• Ključne besede: toxicology, bisphenols A - pharmacokinetics - toxicity, sheep
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta ; FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 9 str.
• Številčenje: Vol. 10, art. 6498
• PID: 20.500.12556/RUL-118010
• UDK: 636.3.09:615.9
• ISSN pri članku: 2045-2322
• DOI: 10.1038/s41598-020-63286-z
• COBISS.SI-ID: 5111162
• Datum objave v RUL: 11.08.2020

Gradivo je del revije

• Naslov: Scientific reports
• Skrajšan naslov: Sci. rep.
• Založnik: Nature Publishing Group
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 16.04.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: toksikologija, bisfenoli A - farmakokinetika - toksičnost, ovce

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0092
• Naslov: Zdravje živali, okolje in varna hrana

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Program financ.: Postgraduate (Ph.D.) research funding