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Sinteza izbranih amidov piruvične kisline
ID Kozlovič, Klemen (Author), ID Kranjc, Krištof (Mentor) More about this mentor... This link opens in a new window

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Abstract
Sledeče diplomsko delo opisuje pripravo štirih različnih amidov piruvične kisline. Sinteze so bile izvedene preko njenega kislinskega klorida (ki je bil iz piruvične kisline pripravljen s pomočjo oksalil klorida), ki je v naslednji stopnji z različnimi amini (dietilamin, cikloheksilamin, anilin, 4-metoksianilin) reagiral do različno substituiranih amidov. Sintetizirane amide smo okarakterizirali s pomočjo IR spektroskopije, 1H NMR spektroskopije, HRMS ter jim izmerili temperaturo tališča.

Language:Slovenian
Keywords:piruvična kislina, oksalil klorid, kislinski kloridi, Schotten – Baumannovi pogoji sinteze amidov, spektroskopija.
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2019
PID:20.500.12556/RUL-109512 This link opens in a new window
COBISS.SI-ID:1538310083 This link opens in a new window
Publication date in RUL:04.09.2019
Views:1228
Downloads:248
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Secondary language

Language:English
Title:Synthesis of selected amides of pyruvic acid
Abstract:
The following diploma thesis describes the synthesis of four different amides of pyruvic acid. The reactions were carried out via corresponding acid chloride (prepared from pyruvic acid with the addition of oxalyl chloride) that was in the next step reacted with a selection of amines (diethylamine, cyclohexylamine, aniline, 4-methoxyaniline) yielding variously substituted amides. The final products were characterised using IR spectroscopy, 1H NMR spectroscopy, HRMS and with melting points measurement.

Keywords:pyruvic acid, oxalyl chloride, acid chlorides, Schotten–Baumann conditions of amides synthesis, spectroscopy

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