Sinteza izbranih amidov piruvične kisline

Kozlovič, Klemen (author), Kranjc, Krištof (mentor)

Sledeče diplomsko delo opisuje pripravo štirih različnih amidov piruvične kisline. Sinteze so bile izvedene preko njenega kislinskega klorida (ki je bil iz piruvične kisline pripravljen s pomočjo oksalil klorida), ki je v naslednji stopnji z različnimi amini (dietilamin, cikloheksilamin, anilin, 4-metoksianilin) reagiral do različno substituiranih amidov. Sintetizirane amide smo okarakterizirali s pomočjo IR spektroskopije, 1H NMR spektroskopije, HRMS ter jim izmerili temperaturo tališča.

• Language: Slovenian
• Keywords: piruvična kislina, oksalil klorid, kislinski kloridi, Schotten – Baumannovi pogoji sinteze amidov, spektroskopija.
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2019
• PID: 20.500.12556/RUL-109512
• COBISS.SI-ID: 1538310083
• Publication date in RUL: 04.09.2019

Secondary language

• Language: English
• Title: Synthesis of selected amides of pyruvic acid

Abstract

The following diploma thesis describes the synthesis of four different amides of pyruvic acid. The reactions were carried out via corresponding acid chloride (prepared from pyruvic acid with the addition of oxalyl chloride) that was in the next step reacted with a selection of amines (diethylamine, cyclohexylamine, aniline, 4-methoxyaniline) yielding variously substituted amides. The final products were characterised using IR spectroscopy, 1H NMR spectroscopy, HRMS and with melting points measurement.

• Keywords: pyruvic acid, oxalyl chloride, acid chlorides, Schotten–Baumann conditions of amides synthesis, spectroscopy