Introduction: Spinal cord injury has a significant impact on life and causes severe sensory, motor and other deficits which limit the execution of activities. It is vital to incorporate the occupational therapy of patients with spinal cord damage into their own home environment, because this approach maximizes the efficiency of learning the performance of daily activities. Purpose: To establish the efficiency of occupational therapy of patients with spinal cord injury in a home setting. We explain the rationale behind this approach and show that it improves the efficiency and patient satisfaction with the performance of daily activities, which consequently improves the quality of life. Methods: We used a case study. We included four members of the Slovenian Paraplegic Association, aged between 36 and 70 years. We evaluated their life satisfaction and the execution of a few select activities, according to the Canadian Occupational Performance Measure and the activity analysis, as well as using a Life Satisfaction Questionnaire, LiSat-11. Results: The outcome of occupational therapy shows a higher satisfaction and efficiency in performing activities, a reduction in skill discrepancies and a higher life satisfaction in all users. Discussion, conclusion: The occupational therapy of patients in a home setting has been shown to be an effective method. We will promote this approach among the members of the Slovene Paraplegic Association.