Razvoj cetilpiridin-alginatnih nanokompleksov s slabo topno učinkovino

Pirnat, Saša (author), Kristl, Julijana (mentor), Mirtič, Janja (co-mentor)

S kompleksiranjem natrijevega alginata s cetilpiridinijevim kloridom v ustreznem molarnem razmerju smo izdelali cetilpiridin-alginatne nanokomplekse, v katere smo vgradili slabo vodotopno učinkovino ibuprofen. Cetilpiridinijevemu kloridu smo določili kritično micelarno koncentracijo in solubilizacijsko kapaciteto za ibuprofen ter na podlagi teh podatkov izdelali nanokompleksez ibuprofenom. Nanokomplekse smo na podlagi njihovih fizikalnih lastnosti (hidrodinamski premer, polidisperzni indeks in zeta potencial) ovrednotili z vidika stabilnosti pri različnih pogojih, določili način sproščanja učinkovine iz nanokompleksov, njihovo morfologijo ter interakcije med komponentami.

• Language: Slovenian
• Keywords: Polielektrolitni kompleksi, topnost, ibuprofen, parodontalna bolezen
• Work type: Master's thesis/paper
• Organization: FFA - Faculty of Pharmacy
• Year: 2019
• PID: 20.500.12556/RUL-108637
• Publication date in RUL: 10.07.2019

Secondary language

• Language: English
• Title: Development of cetylpyridinium-alginate nanocomplexes with a poorly soluble drug

Abstract

Crosslinking sodium alginate with cetylpyridinium chloride in suitable molar ratios, we obtained cetylpyridinium-alginate nanocomplexes with incorporated poorly soluble drug ibuprofen. For cetylpyridinium chloride we determined critical molar concentration and solubilization capacity for ibuprofen. Based on this results we created nanocomplexes with ibuprofen. Measuring their physical properties (i.e. hydrodynamic parameter, polydisperse index and zeta potential) we characterized nanocomplexes from stability's point of view in different conditions, determined drug release, their morphology and interactions between single components.

• Keywords: Polyelectrolyte complexes, solubility, ibuprofen, periodontal disease