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Canine cognitive dysfunction and Alzheimerʼs disease : two facets of the same disease?
ID Prpar Mihevc, Sonja (Avtor), ID Majdič, Gregor (Avtor)

URLURL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/articles/10.3389/fnins.2019.00604/full Povezava se odpre v novem oknu

Izvleček
Neurodegenerative diseases present a major and increasing burden in the societies worldwide. With aging populations, the prevalence of neurodegenerative diseases is increasing, yet there are no effective cures and very few treatment options are available. Alzheimer’s disease is one of the most prevalent neurodegenerative conditions and although the pathology is well studied, the pathogenesis of this debilitating illness is still poorly understood. This is, among other reasons, also due to the lack of good animal models as laboratory rodents do not develop spontaneous neurodegenerative diseases and human Alzheimer’s disease is only partially mimicked by transgenic rodent models. On the other hand, older dogs commonly develop canine cognitive dysfunction, a disease that is similar to Alzheimer’s disease in many aspects. Dogs show cognitive deficits that could be paralleled to human symptoms such as disorientation, memory loss, changes in behavior, and in their brains, beta amyloid plaques are commonly detected both in extracellular space as senile plaques and around the blood vessels. Dogs could be therefore potentially a very good model for studying pathological process and novel treatment options for Alzheimer’s disease. In the present article, we will review the current knowledge about the pathogenesis of canine cognitive dysfunction, its similarities and dissimilarities with Alzheimer’s disease, and developments of novel treatments for these two diseases with a focus on canine cognitive dysfunction.

Jezik:Angleški jezik
Ključne besede:brain, neurodegeneration, cognitive dysfunction, Alzheimer's disease, plaque amyloid, TAU proteins, dogs
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2019
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Založnik:Frontiers Media
Št. strani:Str. 1-18
Številčenje:Vol. 13, No. e604
UDK:636.7.09:616.89
ISSN pri članku:1662-453X
DOI:10.3389/fnins.2019.00604 Povezava se odpre v novem oknu
COBISS.SI-ID:4832378 Povezava se odpre v novem oknu
Datum objave v RUL:26.06.2019
Število ogledov:728
Število prenosov:156
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Gradivo je del revije

Naslov:Frontiers in neuroscience
Skrajšan naslov:Front. neurosci.
Založnik:Frontiers Research Foundation
ISSN:1662-453X
COBISS.SI-ID:15724633 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:26.06.2019

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

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