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The use of ultrasound in the crystallization process of an active pharmaceutical ingredient
ID
Majal Belca, Lucija
(
Avtor
),
ID
Ručigaj, Aleš
(
Avtor
),
ID
Teslič, Dušan
(
Avtor
),
ID
Krajnc, Matjaž
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,69 MB)
MD5: 26663E8FA09D23471C03B821D5D9CE2B
URL - Izvorni URL, za dostop obiščite
https://www.sciencedirect.com/science/article/pii/S1350417719306820
Galerija slik
Izvleček
In this research, ultrasound was used in the crystallization process as an alternative to conventional spontaneous crystallization and seeding crystallization. The study was implemented on an active pharmaceutical ingredient ticagrelor, where the influence of ultrasound on its physical properties was evaluated. Process parameters of spontaneous crystallization, seeding crystallization and ultrasound-assisted crystallization were extensively studied while the pros and cons of each were adequately exposed. Compared to spontaneous crystallization and seeding crystallization ultrasound-assisted crystallization has significantly improved fundamental crystallization parameters: nucleation, the growth of crystals and filtration time. At the same time, the tendency of particles to agglomerate was reduced, which lead to the avoidance of energy and time-consuming process of final product deagglomeration, often problematic in conventional crystallization. In addition, different physical properties of ticagrelor were reached and evaluated, for instance, morphology, particle size distribution and different polymorphic forms. Polymorphic forms I, II and III were efficiently produced in a repeatable, robust and optimal way. Ultrasound-assisted crystallization was proved to have a beneficial effect on the crystallization process of API, even on the industrial scale, and can successfully replace spontaneous crystallization and seeding crystallization.
Jezik:
Angleški jezik
Ključne besede:
crystallization
,
ultrasound
,
active pharmaceutical ingredient
,
ticagrelor
,
physical properties
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2019
Št. strani:
Str. 1-10
Številčenje:
Vol. 58, art. 104642
PID:
20.500.12556/RUL-108115
UDK:
66.09
ISSN pri članku:
1350-4177
DOI:
10.1016/j.ultsonch.2019.104642
COBISS.SI-ID:
1538246083
Avtorske pravice:
V članku navedeno: "© 2019 Elsevier B.V. All rights reserved." Na pristajalni strani članka navedeno: "Under a Creative Commons license"; s povezavo
https://creativecommons.org/licenses/by-nc-nd/4.0/
. (18. 3. 2021) Na pristajalni strani članka tudi povezava "Get rights and content", kjer navedeno tudi: "This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed." (
https://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S1350417719306820&orderBeanReset=true
, 16. 3. 2021)
Datum objave v RUL:
18.06.2019
Število ogledov:
1615
Število prenosov:
473
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Objavi na:
Gradivo je del revije
Naslov:
Ultrasonics Sonochemistry
Skrajšan naslov:
Ultrason. sonochem.
Založnik:
Butterworth-Heinemann, Elsevier Science
ISSN:
1350-4177
COBISS.SI-ID:
707668
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:
18.06.2019
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
kristalizacija
,
ultrazvok
,
aktivna farmacevtska sestavina
,
inhibitor ticagrelor
,
fizikalne lastnosti
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Lek Pharmaceuticals d.d.
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