Introduction: Acute damage to the lower limb, especially ankle and knee injury, is a common and serious problem for team sports. Female athletes have a 3 to 5-fold higher risk of serious knee injury in sports such as football, basketball and volleyball compared to man athletes. The number of non-contact anterior cruciatum ligament injury in women is 2 to 8 times higher than in males. To reduce economic and psychological factors after damage to the lower limb, there are many preventive exercise programs. One of these is the prevention of injury and enhancement of performance (PEP). Furthermore the neuromuscular preventive exercise program is essential in reducing the risk of ankle or knee injury. Purpose: To analyse effects of PEP program on the prevention of knee injuries in female football and basketball players based on the review of scientific literature. Methods: The used articles were collected from PubMED, Pedro, Cochrane Library and Dikul. Articles were published between 2000 and 2018 and written in English. The following key words were used alone or in combination: PEP program, prevent injury and enhancement performance program, knee injury, ACL injury, neuro-muscular prevention program, female, sport injury. Results: Eight studies were included in the thesis of which the results are distributed by individual categories according to the performed measurements. We studied the impact of the PEP program on reducing the number of knee injuries, the different parameters of landing from a jump, the muscle balance between the posterior thigh muscle and the quadriceps and also the height of the vertical jump. Discussion and Conclusion: It has been found that the PEP program can reduce the incidence of knee injury especially the anterior cruciatum ligament. In addition, it can improve the lower limb kinematics in depth jumps and improve the muscle balance of the posterior thigh muscles and quadriceps. However it does not affect the height of the vertical jump or the improvement in the performance of the activities of athletes.