In the modern world, infertility is an increasingly diagnosed disease. There are many causes of infertility, immune infertility being one of them. When it comes to ensuring the optimum conditions for the transport of female and male gametes through the female genital tract, the implantation, and the growth and development of the gametes, the immune status plays an important role. Fertility problems arise at various levels and are thus often difficultly assessed properly. The infertility caused by the immune disorders can be decreased with the help of immunotherapy, which causes immunosupression or immunoregulation.