1. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIs
Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, izvirni znanstveni članek

Ključne besede: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents
Celotno besedilo (datoteka, 6,80 MB) Gradivo ima več datotek! Več...

3. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh, 2021, izvirni znanstveni članek

Ključne besede: antibacterials, DNA gyrase inhibitors, drug discovery, Staphylococcus aureus, intercalators, novel bacterial topoisomerase inhibitors, NBTIs, symmetrical bifurcated halogen bonds, crystal structure, novel NBTIs mechanism of action, antimicrobials, DNA-binding proteins, drug development, X-ray crystallography
Celotno besedilo (datoteka, 2,00 MB) Gradivo ima več datotek! Več...