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4. Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader designRobert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach, 2023, izvirni znanstveni članek Ključne besede: the Petasis borono-Mannich reaction, Strecker synthesis, CRBN ligands
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6. Simulation- and AI-directed optimization of 4,6-substituted 1,3,5-triazin-2(1H)-ones as inhibitors of human DNA topoisomerase IIαBarbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih, 2024, izvirni znanstveni članek Ključne besede: molecular design, molecular simulations, deep learning, human DNA, topoisomerase IIα, catalytic inhibitors, anticancer agents Celotno besedilo (datoteka, 10,65 MB) Gradivo ima več datotek! Več... |
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8. Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheadsLevente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Stanislav Gobec, Izidor Sosič, György Keserü M., 2021, izvirni znanstveni članek Ključne besede: immunoproteasome, benzoxazole-2-carbonitriles, bidentate covalent inhibitors, fragments, non-covalent recognition Celotno besedilo (datoteka, 1,17 MB) Gradivo ima več datotek! Več... |
9. Redox active or thiol reactive?Matic Proj, Damijan Knez, Izidor Sosič, Stanislav Gobec, 2022, pregledni znanstveni članek Ključne besede: redox, covalent, screening, hits, PAINS, assays Celotno besedilo (datoteka, 1,04 MB) Gradivo ima več datotek! Več... |
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