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Terapevtska uporaba mezenhimskih matičnih celic iz maščobnega tkiva pri psu (Canis familiaris).
Ušeničnik, Urška (Author), Dovč, Peter (Mentor) More about this mentor... This link opens in a new window

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Abstract
Prikazan je pomen uporabe mezenhimskih matičnih celic v terapiji različnih bolezni in poškodb kjer zaradi njihovega imunomodulatornega, antiapoptotičnega delovanja in diferenciacijskega potenciala pripomorejo k hitrejši regeneraciji. Za njihovo uspešno uporabo je potrebno znanje o postopkih izolacije, karakterizacije, diferenciacije in shranjevanja celic, ter o različnih dostavnih sistemih, ki se razlikujejo med različnimi terapijami. Diplomsko delo prav tako vsebuje prednosti in slabosti uporabe biomaterialov kot nosilcev pri različnih načinih aplikacije celic, ki lahko zaradi odprtega sistema pripomorejo k njihovemu boljšemu nadzoru in diferenciaciji. Na koncu je delovanje mezenhimskih matičnih celic pri psu prikazano na primeru osteoartritisa, periodontalnih bolezni, regeneracije kože, kroničnih poškodb, kroničnega vnetja črevesja in tumorja.

Language:Slovenian
Keywords:biotehnologija, mezenhimske matične celice, maščobno tkivo, terapevtska uporaba, biomateriali, pes
Work type:Bachelor thesis/paper (mb11)
Tipology:2.11 - Undergraduate Thesis
Organization:BF - Biotechnical Faculty
Year:2017
Publisher:[U. Ušeničnik]
UDC:602.9:591.81(043.2)
COBISS.SI-ID:8812921 Link is opened in a new window
Views:379
Downloads:150
Metadata:XML RDF-CHPDL DC-XML DC-RDF
 
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Secondary language

Language:English
Title:Therapeutic use of canine (Canis familiaris) adipose-derived mesenchymal stem cells
Abstract:
The importance of therapeutic use of mesenchymal stem cells is outlined through their immunomodulatory and antiapoptotic effects as well as differentiation potential, which all contribute to faster regeneration. For successful therapeutic use the knowledge about isolation of mesenchymal stem cells, their characterization, differentiation and preservation is needed. Due to their specific effects different application systems which are adapted to different therapies play an important role. Strengths and weaknesses of biomaterials for different applications are discussed as they can be beneficial because of better control over the cells and their differentiation in an open system. At the end the therapeutic effect of mesenchymal stem cells are presented in the case of osteoarthritis, periodontal disease, skin regeneration, chronical wounds, chronic bowel disease and tumor.

Keywords:biotechnology, mesenchymal stem cells, adipose tissue, therapeutic use, biomaterials, canine

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