Analiza karakteristik farmacevtske vrtinčnoslojne naprave

Plut, Marko (author), Golobič, Iztok (mentor)

V delu je predstavljena vrtinčnoslojna naprava, ki deluje na principu fluidiziranja delcev, pri kateri sta bistvena elementa distribucijska plošča in fluidizirani delci. Glede na določeno gostoto in premere delcev je bilo ugotovljeno, da delci prahu spadajo v skupino prahov A Geldartove karakterizacije, delci pelet pa spadajo v skupino C. V delu so predstavljene računske in eksperimentalne vrednosti tlačnega padca skozi fluidiziran sloj ter skozi distribucijsko ploščo. Tlačni padec pri uporabi delcev prahu je nižji kot pri uporabi delcev pelet, povprečno za 114 Pa. Razlike med izmerjenimi in izračunanimi vrednosti tlačnih padcev se za določen obseg hitrosti dobro ujemajo za delce pelet, do 150 Pa, nasprotno je v primeru prahu, kjer so vrednosti različne za več tisoč Pascalov. Minimalne hitrosti fluidizacije pelet določene eksperimentalno zanašajo med 1,4 in 4 m/s medtem, ko znašajo računske vrednostmi med 0,035 do 0,43 m/s. S pomočjo regresijske analize so predstavljena nova koeficienta Ergunove enačbe, ki znašata 0,417 in 1,089.

• Language: Slovenian
• Keywords: vrtinčnoslojna naprava fluidiziran sloj Geldartova karakterizacija delcev minimalna hitrost fluidiziranja tlačni padec skozi porozni sloj delcev
• Work type: Master's thesis/paper
• Organization: FS - Faculty of Mechanical Engineering
• Year: 2017
• PID: 20.500.12556/RUL-95501
• Publication date in RUL: 20.09.2017

Secondary language

• Language: English
• Title: Analysis of characteristics of pharmaceutical fluid bed device

Abstract

Represented work focuses on fluid bed system, which bases on particles fluidization phenomena where critical elements are distribution plate and particles undergoing fluidization process. Determination of density and mean diameter of particles show us that investigated powder fall under Geldarts A category, meanwhile pellets particles are considered as a group C. The work further focuses on analysis of pressure drop through fluidized bed and through distribution plate. Pressure drop through powder particles is lower due to pellets, for average value 114 Pa. For limited measuring area for pellets show small deviations, up to 150 Pa of measured values from values determined with represented equations. In contrary, in case of powder, differences among measured and calculated results were more that thousand pascals. Minimal fluidization velocities for pellets determined experimentally very between 1,4 and 4 m/s comparable with values from equations which give us values between 0,035 do 0,43 m/s. Based on regression analysis, new coefficients 0,417 and 1,089 of Ergun equation are represented.

• Keywords: Fluid-bed dryer Fluidized bed Geldard particle characteristics Minimum fluidization velocity Pressure drop through fluid bed