Introduction: The most frequent indications for the arterial catheter insertion are the need for frequent arterial blood gas analysis, blood laboratory tests and the expected frequent changes in the arterial blood pressure of a patient. Complications with inserted arterial catheter are many. Inaccurate results in invasive blood pressure measuring and inaccurate arterial blood laboratory findings are also often. Largely responsible in preventing complications is nursing care. Purpose: The purpose is to present the prevention of complications in patient with inserted radial arterial catheter on the theoretical level. The objectives are to demonstrate the specificities of radial arterial catheter management and to create work instructions. Methods: Descriptive method was used with the systematic review and analysis of scientific literature in English and Slovenian language. The results of the thesis was carried out from the systematic review of scientific literature. Basic literature in the English language was searched in the databases CINAHL and PubMed between 2006 and 2016. The literature in Slovenian language was searched through national bibliographic database COBIB.SI between 2006 and 2016. We also reviewed books of expert meetings for nurses. Results: Arterial catheter management without complications is the goal on the way of improving quality and safety, which in practice means using methods based on scientific evidence and undertaken by suitably qualified nurses. The recommended frequency of introduced radial arterial catheter control is at least once per shift. Inaccurate results of arterial blood laboratory analysis are blood contamination, the presence of bubbles in the tube and inaccurate handling with the tube prior to or during transport. Addition of heparin to the infusion solution is not necessary in the majority of patients. Evidence-based knowledge can be introduced into practice through work instructions, available in electronic form, and check-lists at bedside, which are used for documenting, reporting and also for further research to improve the safety and quality of nursing care. Discussion and conclusion: Research of the arterial catheter management introduced into daily practice is required. This results in improving the safety and quality of patient centred nursing care, the acquisition of new knowledge and the transfer of new knowledge into practice.