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Modeliranje kinetike vezave monoklonskih protiteles na receptor FcγRIIIa
Čufar, Matija (Author), Zupan, Blaž (Mentor) More about this mentor... This link opens in a new window, Mramor Kosta, Nežka (Co-mentor)

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Abstract
Matematično modeliranje postaja vedno bolj pomembno področje sodobne biologije. V diplomskem delu smo razvili model, ki opisuje dinamiko vezave med dvema vrstama protiteles in receptorjem FcγRIIIa. Naš cilj je bil najti metodo, ki bo iz eksperimentalnih podatkov določila parametre modela. Za najboljšo metodo se je izkazal Levenberg-Marquardtov algoritem, ki deluje zelo učinkovito in zanesljivo ter poišče parametre modela tako, da se obnašanje modela dobro ujema s podatki. Rezultati metode predstavljajo ocene pomembnih fizikalnih parametrov, ki bi se lahko izkazali za uporabne pri karakterizaciji biološkega zdravila.

Language:Slovenian
Keywords:matematično modeliranje, imunski sistem, monoklonsko protitelo, receptor, interferometrija z biološkimi plastmi, optimizacija, Levenberg-Marquardtov algoritem, prilagajanje funkcij
Work type:Bachelor thesis/paper (mb11)
Organization:FRI - Faculty of computer and information science
Year:2016
Views:443
Downloads:257
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Secondary language

Language:English
Title:Kinetic modelling of binding between monoclonal antibodies and the FcγRIIIa receptor
Abstract:
Mathematical modelling is becoming an increasingly important part of life sciences. This thesis deals with a mechanistic biological model of binding between two kinds of antibodies and the FcγRIIIa receptor. Our goal was to develop a method that would determine the model parameters to match experimental data. The best method turned out to be the Levenberg-Marquardt algorithm, which is surprisingly reliable and fitted the model to the data well. The results give us an estimate of important physical parameters of the antibody that can be useful in the characterization of a biopharmaceutical drug.

Keywords:mathematical modelling, immune system, monoclonal antibody, receptor, bio-layer interferrometry, optimization, Levenberg-Marquardt algorithm, curve fitting

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