Introduction: ankle injury is one of the most common injuries in sports, accounting for 20% of all sport injuries .Therefore it is very important to have a good preventive strategy, which can limit the frequency of such injuries and at the same time ensure an optimal economical solution. Purpose: the purpose of this thesis is to present function and effects of serial ankle orthoses used at activities. Methods: descreptive method of work with systematic analysis of literature was used. The literature is not older than 10 years. In search of the latter Cobiss, Google Scholar, PubMed, Science Direct and DiKUL were used. Search of results were both in slovenian and english language. Results: we have examined eight professional articles with a direct connection to the topic, directed exclusively to the practical application of serial ankle orthoses at activities. Subjects in researches were mostly amateur or professional athletes, whose results were measured in an average span of one year, or season. In each research, a control group method was used, where the control group did not use orthoses, where the comparison group used them. Therefore they used comparison factors in the final outcome for all the studies. Discussion and conclusion: the results showed that serial ankle orthoses and similar supports have a positive effect on the outcome and have proved to reduce the incidence of the damaged ankle. While designing preventive strategies we still need more knowledge and the awareness of users and experts, which is still used insufficiently.