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SISTEM ZA DOZIRANJE VOLUMSKIH ENOT ZDRAVILNIH UČINKOVIN
GOSTENČNIK, URBAN (Author), Možek, Matej (Mentor) More about this mentor... This link opens in a new window

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Abstract
V diplomskem delu je predstavljena zasnova, razvoj in izdelava naprave, ki uporabniku zagotavlja doziranje konstantnih volumskih enot zdravilne učinkovine (npr. insulin). Izdelana naprava bi nadomestila obstoječe mehanske sisteme. Za ta namen sta bila v Laboratoriju za mikrosenzorske strukture in elektroniko (LMSE) razvita prototipa piezoelektrične mikročrpalke in rezervoarja z elastično membrano za shranjevanje zdravilne učinkovine. Glavni cilj diplomskega dela je v kontroli elektronskega modula, ki je sestavljen iz mikrokrmilniške razvojne plošče z zaslonom občutljivim na dotik, generatorja visokonapetostnega signala in piezo rezistivnega tlačnega senzorja. Med procesom doziranja, piezoelektrična mikročrpalka črpa zdravilno učinkovino iz rezervoarja, ki je prekrit z elastično membrano. Izpodrinjen volumen povzroči povišanje podtlaka v rezervoarju. Ta podtlak merimo s pomočjo piezo rezistivnega tlačnega senzorja. Količino prečrpane zdravilne učinkovine lahko izračunamo s pomočjo meritev tlaka v rezervoarju in s poznavanjem odvisnosti med tlakom in volumnom v rezervoarju. Tej odvisnosti pravimo tudi karakteristika rezervoarja. Poleg osnovnega delovanja doziranja zdravilne učinkovine, smo za osebni računalnik izdelali še posebno aplikacijo za merjenje karakteristike rezervoarja. Med procesom merjenja karakteristike rezervoarja smo mikročrpalko nadomestili z motoriziranim dozirnikom z brizgo. Naloga aplikacije je, da sinhronizira delovanje med mikrokrmilniško razvojno ploščo in motoriziranim dozirnikom z brizgo. Poleg tega aplikacija omogoča še pošiljanje izmerjene karakteristike na mikrokrmilnik. Za doziranje ene doze zdravilne učinkovine mikrokrmilnik najprej izmeri tlak v rezervoarju. Na podlagi te meritve in karakteristike rezervoarja mikrokrmilnik izračuna ciljni tlak v rezervoarju po prečrpanju doze. Proces črpanja se zaključi, ko je v rezervoarju dosežen ciljni tlak. Prestavljen princip doziranja je zelo odvisen od kvalitete polnjenja sistema. Vsakršni zračni mehurčki, ki se ujamejo v sistemu lahko povzročijo napako pri doziranju. Te zračne mehurčke lahko zaznamo s kontinuiranim merjenjem tlaka v rezervoarju. Vsak nenaden padec tlaka kaže na prisotnost zračnih mehurčkov v rezervoarju.

Language:Slovenian
Keywords:mikročrpalka, rezervoar, tlak, mikrokrmilnik, doziranje, karakterizacija
Work type:Undergraduate thesis (m5)
Organization:FE - Faculty of Electrical Engineering
Year:2016
Views:716
Downloads:268
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Secondary language

Language:English
Abstract:
This diploma thesis presents design, development and implementation of a system for dosing of constant volumetric units of active drug ingredient (for example insulin). Implemented device should replace existing mechanical systems. The system was implemented using piezoelectric micropumps and a reservoir with a flexible membrane prototypes, recently developed in the LMSE (Laboratory of Microsensor Structures and Electronics). The main focus of presented thesis is on control electronic module, comprised of a microcontroller development board with touch-screen, a high voltage generator for driving the piezoelectric micropumps and a piezoresistive pressure sensor. During the dosing process, the piezoelectric micropump sucks drug ingredients from a reservoir, which is covered with a flexible membrane. The displaced volume causes a rise of vacuum pressure in the reservoir. This vacuum pressure is measured with a piezoelectric pressure sensor. The change of dosing volume can be calculated by monitoring the pressure drop and knowing the reservoir pressure vs. volume characteristic - also known as the reservoir characteristic. In addition to normal dosing operation, dedicated algorithms were programmed on a PC for accurate evaluation of reservoir characteristic. During measurement of reservoir characteristics, the micropump was replaced with a motorized syringe pump. The PC application synchronizes operation between microcontroller development board and a motorized syringe pump. Furthermore, this application also enables the download of calculated piecewise linear approximation description of reservoir characteristic to the microcontroller. For dispensing a single dose of active drug ingredient, the microcontroller initially measures the tank pressure. Based on this measurement, the tank characteristic piecewise linear approximation coefficients are evaluated and target tank pressure is calculated. The dosing process is stopped, when this target pressure value is achieved. Presented dosing approach is heavily dependent on quality of reservoir priming. Any residual air, contained in the dosing system causes a dosing error. Such residual air pockets can be detected by continuously monitoring the pressure drop - any sudden distortion in pressure drop will indicate presence of air in the system.

Keywords:micro pump, reservoir, pressure, microcontroller, dosing, characterization

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