The response of the cambial zone to wounding and infection is a complex process which involves the formation of protective tissues and regeneration ofthe secondary vascular tissue system. At wound margins the response includesthe formation of callus, the development of primary ligno-suberised layer and new periderm on the surface of the callus and new vascular cambium inside it. Through the activity of the new vascular cambium the process of wound closures starts. The barrier zone (CODIT) is a specialised tissue, formed distally from the wound margins as a response of the cambial zone, extant at the time of injury. Factors influencing the variability of response are reviewed.