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Ecotoxicologically relevant cyclic peptides from cyanobacterial bloom (Planktothrix rubecens) - a threat to human and environmental health
Sedmak, Bojan (Author), Eleršek, Tina (Author), Grach-Pogrebinsky, Olga (Author), Carmeli, Shmuel (Author), Sever, Nataša (Author), Lah Turnšek, Tamara (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-I5AOW6B1 This link opens in a new window

Abstract
Background. The information of the overall production of major cyanobacterial cyclic peptides in a water body is essential for risk assessment and for the prediction of future development of the bloom. A procedure that gives a reviewof both toxic and non-hepatotoxic hydrophilic cyclic peptide production is important to evaluate the ecological conditions in the water environment and to predict the release of dangerous toxic and tumour promoting substances.Methods. The cyclic peptides were identified on the basis of their retention times, characteristic spectra, molecular masses and biological activity. The non-hepatotoxic cyclic peptides were characterised by their inhibition of porcine pancreatic elastase, while cytotoxicity to mammalian cells was tested with the MTT test on B16 cell line. Conclusions. The method presented gives a rapid, simultaneous assessment, preliminary identification and estimation of bioactive cyclic peptides. The synthesis of non-hepatotoxic cyclic peptides can mediate the release various toxic and otherwise biologically active substances that induce systemic genotoxicity in mammals.

Language:English
Keywords:tumor promoters, microcystin, anabaenopeptin, planktopeptin, toxic cyanobacterial blooms, environmental health
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
Year:2008
Publisher:Croatian Medical Association - Croatian Society of Radiology
Number of pages:str. 102-113
Numbering:Vol. 42, no 2
UDC:577
ISSN on article:1318-2099
DOI:10.2478/v10019-088-0001-9 Link is opened in a new window
COBISS.SI-ID:1861199 Link is opened in a new window
Views:594
Downloads:261
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 This link opens in a new window

Secondary language

Language:Slovenian
Title:Ekotoksikološko pomembni ciklični peptidi iz cianobakterijskega cveta (Planktothrix rubescens) - grožnja človeškemu in okoljskemu zdravju

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