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Nekatere prehranske možnosti za preprečitev škodljivega vpliva fuzarijskih toksinov (T-2 in DON) na proizvodne lastnosti in lipidno peroksidacijo pri piščancih
ID Rezar, Vida (Author), ID Korošec, Tamara (Author), ID Salobir, Janez (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-AHMO043R This link opens in a new window

Abstract
Mikotoksini, sekundarni metaboliti gliv, so strupeni tako za ljudi, kot tudi za živali. Prisotnost fuzarijskih toksinov (T-2 toksina in deoksinivalenola (DON-a)) v krmi, predvsem v višjih koncentracijah, vpliva na zmanjšanje zauživanja krme, posledično pa tudi na prirast živali in zmanjšano težo živali, kar lahko povzroča večje ekonomske izgube. Novejše raziskave so pokazale, da toksini v krmi vplivajo tudi na imunsko odpornost organizma in povzročajo oksidacijski stres oz. povečano lipidno peroksidacijo v organizmu. Namen predstavljenih raziskav je bil ugotoviti vpliv stopnjevane koncentracije T-2 toksina v krmi (od 0,5 do 13,5 mg/kg) in koncentracije 10 mg/kg T-2 toksina in DON-a na proizvodne lastnosti in oksidacijski stres, pri rastočih piščancih, ter ugotoviti potencialni prehranski vpliv mikotoksinskega vezalca in nukleotidov na zmanjšanje negativnih vplivov fuzarijskih toksinov. Rezultati so pokazali, da koncentraciji 10 in 13,5 mg/kg T-2 toksina vplivata na zmanjšanje zauižvanja krme in slabše priraste. Deset in 13,5 mg/kg T-2 toksina in 10 mg/kg DON-a v krmi povzroči poškodbe DNA v levkocitih, merjene s kometnim testom. Rezultati dokazujejo, da lahko z dodajanjem mikotoksinskega vezalca v krmo vsaj delno preprečimo absorpcijo mikotoksinov iy črevesja in tako zmanjšamo njihov negativni vpliv na oksidacijski stres (primerjava med skupinama z in brez dodatka s 13,5 mg T-2 toksina/kg krme), medtem ko z dodajanjem nukleotidov lahko vplivamo na mehanizme popravljanja poškodb DNA imunskih celic, ki so jih povzročili fuzarijski toksini.

Language:Slovenian
Keywords:perutnina, pitovni piščanci, prehrana živali, krma, mikotoskini, fuzarijski toksini, lipidna peorksidacija, proizvodne lastnosti
Work type:Not categorized
Typology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
Publisher:Biotehniška fakulteta
Year:2008
Number of pages:Str. 19-27
Numbering:Letn. 92, št. 1
PID:20.500.12556/RUL-57899 This link opens in a new window
UDC:636.5.084/.087
ISSN on article:1581-9175
COBISS.SI-ID:2408072 This link opens in a new window
Publication date in RUL:10.07.2015
Views:2037
Downloads:258
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Record is a part of a journal

Title:Acta agriculturae Slovenica
Shortened title:Acta agric. Slov.
Publisher:Biotehniška fakulteta
ISSN:1581-9175
COBISS.SI-ID:213840640 This link opens in a new window

Secondary language

Language:English
Title:Some nutritional strategies in prevention of detrimental influence of Fusarium toxins (T-2 and DON) on production parameters and lipid peroxidation in chickens
Abstract:
Mycotoxins, a group of secondary fungal metabolites, are toxic for people and animals. Presence of Fusarium toxins (T-2 toxin and deoxinivalenol (DON)) in feed, especially in higher concentrations, reduces feed consumption and consequently live weight gain, which can cause higher economic losses. Recent studies showed that toxins in feed influence the action of the immune system and cause oxidative stress. The objective of the present studies was to: (i) establish the dose dependant effect of T-2 toxin (from 0.5 to 13.5 mg/kg) on production parameters and oxidative stress in broiler chickens, (ii) test the effect of commercial mycotoxin binder at the highest used concentration of T-2 toxin (13.5 mg/kg), and (iii) test the protective effect of nucleotides at high T-2 toxin and DON intoxication (10 mg/kg). Results showed that concentrations of 10 and 13.5 mg/kg of T-2 toxin reduced the feed consumption and live weight gain. T-2 toxin at 10 and 13.5 mg/kg and DON at 10 mg/kg caused DNA damage in leucocytes measured by comet assay. Results proved that supplementation with mycotoxin binder can partly reduce the absorption of mycotoxins from intestine and thus decrease their negative influence on oxidative stress. The crucial role of nucleotide supplementation in feed is to repair DNA damage in immune cells, which are highly sensitive to mycotoxin action.

Keywords:poultry, broiler chickens, animal nutrition, feed, mycotoxins, Fusarium toxins, lipid peroxidation, production parameters

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